Obezitede Lipid Metabolizması İle İlgili Micro RNA’lar

Obezite Metabolik Sedrom, dislipidemi, Tip 2 Diabetes Mellitus ve kardiovasküler hastalık gibi kronik hastalıklar için major risk faktörüdür. Son yıllarda obezitenin moleküler temelinin anlaşılmasında ilerlemelere rağmen, obezite’ye karşı kullanılan ilaçlar fizyolojik spesifite eksikliğine ve yan etkilere sahiptir. MicroRNA’lar miRNA , kısa ~22 nt , kodlanamayan endojen RNA molekülleridir ve mRNA’nın 3’ untranslated bölgesine bağlanarak birçok geni transkripsiyon sonrası düzenler. Bir miRNA birçok hedeflere sahiptir. Gelecekte miRNA’lar kronik hastalıklarının erken teşhisine yardımcı olacak ve yeni terapötik hedefler sağlayacaktır. miRNA’lar obezitede lipid metabolizması düzenlenmesinde bildirilmiştir. Bu derlemede adiposit biyolojisi ve obezite ile arasındaki ilgi, miRNA biyogenezi, düzenlenmesi, fonksiyonları ve obezitede lipid metabolizmasının düzenlenmesindeki rolü incelenecektir

Micro Rnas Related Lipid Metabolism In Obesity

Obesity is a major risk factor for chronic disease such as metabolic syndrome, dyslipidemia, type 2 diabetes mellitus and cardiovascular disease. In recent years, despite advances in understanding the molecular basis of obesity, drugs used against obesity have side effects and lack of physiological specificity. MicroRNAs miRNAs are short ~ 22 nt , noncoded and endogenous RNA molecules and binding to mRNA 3 ‘untranslated region of many genes regulated post-transcriptional. A miRNA has many target genes. In the future, miRNAs will help in early diagnosis of chronic diseases and will provide new therapeutic targets. The miRNA in obesity have been reported in the regulation of lipid metabolism. In this review, adipocyte biology and the relation between obesity, miRNA biogenesis, regulation, function and role in the regulation of lipid metabolism in obesity will be focused

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