Fatma ŞİMSEK, Nuray BİLGE, Mustafa CEYLAN

MIGREN KLINIK ÖZELLIKLERININ NÖTROFIL-LENFOSIT ORANI ILE İLIŞKISI

Giriş: Migrenin ciddi sosyal ve ekonomik etkisi vardır. Migren atakları trigeminal sinir uyarılması ve nörojenik inflamasyonla ilişkilidir. Atak sıklığının bazı enflamatuar belirteçlerle ilişkili olduğu bildirilmiştir. Nötrofiller akut faz reaksiyonlarında inflamatuar cevaba yol açan en önemli hücrelerdir. Nötrofil/Lenfosit oranının N/L birçok hastalıkta prognoz ve mortalite ile ilişkili olduğu bildirilmiştir. Materyal-Metod: Çalışmaya 18–45 yaş arası hastalar ve kontrol grupları dâhil edildi. Hasta ve kontrol grupları ile N/L oranı arasında ilişki araştırıldı. Bulgular: Migren atak ile kontrol grubu N/L oranı arasında istatistiksel olarak anlamlı fark vardı, ancak non-atak ile kontrol grupları karşılaştırıldığında farklı tespit edilmedi. Migren klinik özellikleri, VAS ve MIDAS ile N/L arasında ilişki tespit edilmedi. Tartışma: N/L oranı migren atakları ile ilişkilidir. Ancak, N/L oranı ile hastalık süresi, atak süresi ve ağrı sıklığı, ağrı şiddeti ve hastalık disabilitesi tahmin edilemez.

The Relationship of Migraine Clinical Features With Neutrophil- Lymphocyte Ratio

Purpose: Migraine is associated with serious social and economic burdens. Migraine attacks are associated with trigeminal nerve stimulation and neurogenic inflammation. It has been reported that the frequency of the attacks and disease progression are related to certain inflammatory indicators. Neutrophils are the paramount cells in causing inflammatory response during acute phase reactions. Neutrophil/Lymphocytes ratio N/L has been associated with the prognosis and mortality of several diseases.Methods and Materials: The patients and control group in the age range of 18–45 years were included in the study. The relationship between N/L ratio in patients and control group was investigated.Results: There was a statistically significant difference between the N/L ratios determined during the migraine attacks and the N/L ratio values obtained in the control group. But the non-attacks were not different compared to those of the control group. No statistically significant relationships of N/L ratio were detected with any of the clinical features of migraine, VAS and MIDAS.Conclusions: The N/L ratio is associated with a migraine attack. However, with N/L ratio, disease duration, attack duration, pain frequency and pain severity; the disease disability cannot be predicted

Keywords:

Migraine, neutrophil/lymphocyte ratio, inflammatory pathophysiology,

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