Osman Can YONTAR, Hekim KARAPINAR, Ahmet YILMAZ, İbrahim GÜL, Zekeriya KÜÇÜKDURMAZ, Alim ERDEM

Relationship between metabolic syndrome and non-dipping blood pressure pattern in obese patient

Amaç: Metabolik sendrom ve non -dipper kan basıncı paternikardiyovasküler hastalıklarla ilişkilidir. Bu klinik durumlarınortak patofizyolojik mekanizmalarıyla ilişkili olabilir. Metab olik sendrom ile non -dipper kan basıncı arasındaki ilişkiyiaraştırmayı amaçladık.Yöntem: 24 saatlik ambulatuar kan basıncı takibi yapılanyeni tanı almış 118 obez metabolik sendromlu hasta çalışmamıza dahil edildi. Bunlar dipper (n = 46) ve non -dipper (n= 72) olmak üzere iki gruba ayrıldı. Gece non -dipper kanbasıncı, gece ortalama sistolik ve/veya diastolic kan basıncıazalması %10 dan daha az azalma oluşu olarak tanımlandı.Bulgular: Ça lışma gurubumuzun ortalama 24 saatlik kanbasıncı ortalaması 146/96 mmHg idi. İki grubun temel karakteristik özellikleri benzer olmasına rağmen, non -dippertansiyon paterni olan grupta metabolik sendrom sıklığı a nlamlı derecede daha fazla idi (p=0.038).Sonuç: Bu çalışmada non -dipper kan basıncı paterni olanhastalarda metabolik sendromun daha fazla bulunduğusaptandı . Bu durum, obez hastalarda metabolik sendrom ilenon-dipper kan basıncının ortak bir patofizyolojik mekanizma içerdiğini belirtebilir.

Obez hastalarda non-dipper kan basıncı ile metabolik sendrom arasındaki ilişki

Background: Metabolic syndrome and non -dipping bloodpressure pattern are related with cardiovascular disease. Itis considered that there may be common pathophysiologicalmechanisms of these clinical entities. We aimed to investigate the association between metabolic syndrome and nondipping blood pressure pattern. Method: 118 consecutive newly diagnosed metabolic syndrome patients with obesity who underwent 24 -hour ambulatory blood pressure monitoring were included in the study.They were divided into dipper (n = 46) and non -dipper (n =72) groups. Nocturnal non -dipping blood pressure pattern isdefined as the lower than 10 % reduction in nocturnal meansystolic and/or diastolic blood pressure. Results: In the whole population, mean 24 -hour ambulatoryblood pressure was 146/96 mmHg. Although, the twogroups was similar in terms of basic characteristics; thefrequency of metabolic syndrome was significantly greaterin patients with non -dipping pattern (p=0.038). Conclusion: In this study metabolic syndrome was fou nd tobe more prevalent among patients with non -dipping patternof hypertension. This may indicate a common pathophysi ologic mechanism of metabolic syndrome and non -dippingblood pressure pattern in obese patient.

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