Şafak ŞAHİN, Faruk KUTLUTÜRK, Türker TAŞLIYURT, Banu ÖZTÜRK, Berna YELKEN

N-Terminal Pro B-Tip Natriüretik Peptit ve Vücut Kitle İndeksi arasındaki ilişki

Amaç: N-terminal pro B-tip natriüretik peptid NT-pro BNP hacim genişlemesinde yanıt olarak kardiyak ventriküllerden salgılanır. Natriüretik peptid üzerine obezitenin etkisi henüz tam olarak aydınlatılmış değildir. Bu çalışmada normal kilolu ve obez bireylerde NT-pro BNP düzeylerinin karşılaştırılması amaçlandı. Yöntem: Çalışmaya kırkiki obez hasta 37 kadın, 5 erkek; vücut kitle indeksi ≥ 30 ve normal kilolu otuzbeş kişi 27 kadın, 8 erkek; vücut kitle indeksi ≤ 25 kontrol grubu olarak alındı. Hasta ve kontrol grubunun NT-pro BNP düzeyleri karşılaştırıldı. Bulgular: NT-pro BNP düzeyleri obez hastalarda kontrol grubuna göre anlamlı olarak yüksek bulundu p=0.027 . Vücut kitle indeksi ile NT-pro BNP arasında korelasyon yoktu. Obez hastalarda sistolik ve diyastolik kan basınçları istatistiksel olarak yüksekti sırasıyla; p

Anahtar Kelimeler:

obezite, N-terminal pro B-tip natriüretik peptid, hipertansiyon

Relationship between N-Terminal Pro B-Type Natriuretic Peptide and Body Mass Index

Objective: N-terminal pro B-type natriuretic peptide NT-pro BNP is secreted from the cardiac ventricles in response to volume expansion. The effect of obesity on natriuretic peptide has yet to be fully elucidated. We aimed to compare the NT-pro BNP levels in obese and in healthy individuals with normal body mass index. Method: Forty-two obese patients 37 women, 5 men; body mass index ≥ 30 and thirty-five normal body mass index individuals 27 women, 8 men; body mass index ≤ 25 were analyzed regarding NT-pro BNP. Results: The serum levels of NT-pro BNP was significantly higher in obese patients than normal body mass index individuals p=0,027 . No correlation was found between body mass index and NT-pro BNP. Statistically significant difference was found between systolic and diastolic blood pressures in both groups p

Keywords:

obesity, N-terminal proB-type natriuretic peptide, hypertension,

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