Cemento-ossifying fibroma is a benign fibro-osseous lesion in which normal bone is replaced by fibrous tissue containing variable amounts of mineralized material. Patients in the 3rd to 4th decades are most affected, with a high female-to-male ratio. The lesion can attain a huge size that commonly presents as a progressively growing behaviour if left untreated. Ossifying fibromas require more extensive treatment than other fibro-osseous lesions, such as fibrous dysplasias and osseous dysplasias, because they are true neoplasms. This paper reports a case of a cemento-ossifying fibroma, together with the clinical, radiological, and histopathological features, surgical treatment, and findings at the 2-year follow-up.
Semento-ossifiye fibrom; normal kemiğin çeşitli miktarlarda mineralize materyal ihtiva eden fibröz doku ile yer değiştirdiği iyi huylu fibro-osseöz bir lezyondur. Yaşamın sıklıkla 3. ve 4. dekadında etkilenen hastalarda kadınlar erkeklere oranla daha fazla etkilenmektedir. Lezyon eğer tedavi edilmezse genellikle giderek büyüyen bir davranış ortaya koyar ve oldukça geniş boyutlara ulaşabilir. Ossifiye fibromlar, gerçek birer neoplazm oldukları için fibröz displaziler ve osseöz displaziler gibi diğer fibro-osseöz lezyonlara göre daha kapsamlı tedavi gerektirirler. Bu makalede klinik, radyolojik bulguları, histopatolojik özellikleri, cerrahi tedavisi ile birlikte 2 yıl takipli bir semento-ossiyife fibrom olgusu sunulmuştur.
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1. Kaushik SK, Shashidevi H, Nitesh N. Cemento-ossifying fibroma of the mandible: a benign but potentially destructive tumor. Oral and Maxillofacial Pathology Journal 2015; 6: 561-564.
2. Barnes L, Everson J, Reichart P, Sidransky D. World Health Organisation Classification. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC Press, 2005: 319-320.
3. Young N, Rowson JE. Cementifying fibroma of the frontal bone: a case report. British Journal of Oral and Maxillofacial Surgery 2007; 45: 667-669.
4. Dal Cin P, Sciot R, Fossion E, Van Damme B, Van den Berghe H. Chromosome abnormalities in cementifying fibroma. Cancer Genet Cytogenet 1993; 71: 170-172.
5. Nour Z, Paul MS, Lisette M. Ossifying fibromas of the jaws and craniofacial bones. Diagnostic Histopathology. 2015; 21: 351-358.
6. Eversole LR, Leider AS, Nelson K. Ossifying fibroma: a clinicopathologic study of sixty-four cases. Oral Surg Oral Med Oral Pathol. 1985; 60: 505-511.
7. Thompson, Lester DR. Head and Neck Pathology second edition. 2014: 351-355.
8. Eversole R, Su L, El Mofty S. Benign fibro-osseous lesions of the craniofacial complex: A review. Head and Neck Pathology 2008; 2: 177-202.
9. Gopinath D, Beena VT, Sugirtharaj G, Vidhyadharan K, Salmanul Faris K, Kumar SJ. Cemento-ossifying fibroma in a patient with end-stage renal disease. Case Reports in Dentistry 2013: 1-4.
10. Rangila R, Anita S, Parul S. Cemento-ossifying fibroma. Contemp Clin Dent. 2012; 3:83-85.
11. Gollin SM, Storto PD, Malone PS, Washington JA, Chidambaram A, Barnes L et al. Cytogenetic abnormalities in an ossifying fibroma from a patient with bilateral retinoblastoma. Genes Chromosomes Cancer 1992; 4: 146- 152.
12. Pimenta FJ, Gontijo Silveira LF, Tavares GC, Silva AC, Perdigao PF, Castro WH et. al. HRPT2 gene alterations in ossifying fibroma of the jaws. Oral Oncol 2006; 42: 735- 739.
13. P. Herbozo Silva, C. Mayer Olivares, I. Vargas Farren. Cemento-ossifying fibroma: clinical, radiological and histological analysis of 3 cases in one family. International Journal of Oral and Maxillofacial Surgery 2011; 40: 1182.
14. Patel MM, Wilkey JF, Abdelsayed R, D’Silva NJ, Malchoff C, Mallya SM. Analysis of GNAS mutations in cemento-ossifying fibromas and cemento-osseous dysplasias of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 109: 739-743.
15. Shi RR, Li XF, Zhang R, Chen Y, Li TJ. GNAS mutational analysis in differentiating fibrous dysplasia and ossifying fibroma of the jaw. Mod. Pathol. 2013; 26: 1023-1031.
16. Naik RM, Guruprasad Y, Sujatha D, Gurudath S, Pai A, Suresh K. J . Giant cemento-ossifying fibroma of the mandible. Nat Sci Biol Med 2014; 5:190-194.
17. MacDonald-Jankowski DS, Li TK. Ossifying fibroma in a Hong Kong community: clinical and radiological features and outcomes of treatment. Dentomaxillofacial Rad. 2009; 38: 514-23.
18. Lee YB, Kim NK, Kim JY, Kim HJ. Low-grade osteosarcoma arising from cemento-ossifying fibroma: a case report. J Korean Assoc Oral Maxillofac Surg 2015; 41: 48- 51.