Dilde mikroinvaziv karsinom: Bir olgu sunumu
Dünya Sağlık Örgütü raporuna göre oral skuamöz hücreli karsinom oral kavitenin en sık gö-rülen malignitesidir. Teşhis ve tedavideki ilerlemelere rağmen hastaların 5 yıllık sağkalım oranları belirgin bir şekilde iyileştirilememiştir. Oral kanserlerin erken evrede teşhisi bu sebeple önemlidir. Kliniğimize başvuran 55 yaşında erkek hasta sistemik olarak sağlıklıdır ve sigara kullanmadığını belirtmiştir. Hastanın yapılan ağız içi muayenesinde dil lateralinde yüzeyden kabarık hiperkeratotik lökoplaki tespit edilmiştir. Hasta lezyonun varlığından haberdar değildir ve herhangi bir klinik semptom yoktur. Eksizyonel biyopsi sonrasında yapılan histopatolojik incelemede yüksek dereceli displazi görülmüştür. Mikroskopik bir odakta bazal membran devamlılığının bozulduğu ve mikroinvaziv patern geliştiği gösterilmiştir. Histopatolojik olarak mikroinvaziv karsinom tanısı konulmuştur. Mikroinvaziv karsinom en erken evre malignitedir ve oral kanserlerin bu evrede teşhis edil-mesi, prognozun iyileştirilmesi ve sağkalım oranlarının arttırılması için önemli bir yere sahiptir.
Microinvasive carcinoma of the tongue: A case report
According to World Health Organization Report oral squamous cell carcinoma is the most common malignancy of the oral cavity. Despite many diagnostic and therapeutic advances patients' 5-year survival rates have not been significantly improved. Early diagnosis of oral carcinoma is the-refore important. Systemically healthy, 55 year-old male patient referred to our clinic stated that he does not smoke. Hyperkeratotic leukoplakia was observed on the lateral side of the tongue. The patient had no symptoms and the lesion was observed incidentally. The histopathological examina-tion, which was performed following excisional biopsy showed high grade dysplasia. Basal memb-rane continuity was lost in a microscopic focus and microinvasive pattern was observed. The diag-nosis was established as microinvasive carcinoma. Microinvasive carcinoma is the initial stage of malignancy and the diagnosis of such lesions at this stage is important for the improvement in prognosis and survival rates.
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