Kedi ve köpeklerde kardiyovasküler Hastalıkların tanısında Natriüretik peptidler’in önemi
Kalp yetmezliği ile ilgili hastalıkların patofizyolojisinin anlaşılması ve sağaltımı hakkında son yıllarda oldukça fazla ilerlemeler kaydedilmiştir. Hastalığın tanısında detaylı fiziksel muayeneler yapılmasına rağmen kedi ve köpeklerde yine de zorluklarla karşılaşılmaktadır. Kalp hastalıklarının klinik tanısında; anamnez, fiziksel muayene, kardiyopulmoner oskültasyon ve göğüs radyografisinden yararlanılmaktadır. Tanıda daha çok anlam ifade eden ekokardiyografi kullanımı ve uygulaması uzmanlık gerektirmekte ve aynı zamanda hayvan sahibine ek bir maliyet yüklemektedir. Bu nedenle serum biyomarkırları kalp hastalıklarının tanısı ve sağaltıma verilen cevabın belirlenmesinde kullanılmaktadır. Natriüretik peptidler kalp hastalıklarının tanısında önemli bir yer tutmaktadırlar. Natriüretik peptidler; natriürezisi, idrar üretimini ve böbrek kan akımını arttırırken, sistemik damar direncini ve kalpte dolum basıncını azaltarak diyastololik fonksiyonu etkilemektedir. Kalp hastalıklarının tanısı belirlemede önemli bir protein olmasından dolayı natriüretik peptidlerin kullanımı gittikçe yaygınlaşmaktadır. Bu derlemenin amacı; kalp hastalıklarının tanısında natriüretik peptidlerin etkinliğinin irdelenmesi amaçlanmıştır.
Anahtar Kelimeler:
kedi, kalp damar hastalıkları, kalp hastalıkları, köpek, tanı teknikleri, teşhis
The importance of Natriuretic peptide on diagnosis of heart diseases of dogs and cats
Tremendous advances have been made in understanding of the pathophysiology and treatment of heart failure. However, diagnosis of the disease still remains difficult, even with a comprehensive physical examination in dogs and cats. Clinical assessment of heart disease in dogs and cats has traditionally relied on evaluations of history and results of physical examination, cardiopulmonary auscultation, and thoracic radiography. Methods with greater quantitative value, such as echocardiography, generally require additional expertise to perform and interpret as well as additional financial cost to the owner. Thus, a biomarker that could be used to help detect cardiac disease in dogs and cats assess disease severity would be useful clinically. Natriuretic peptide is a potential biomarker of cardiac disease. Natriuretic peptides increases natriuresis, urine production, and renal blood flow; enhances diastolic function, decreases systemic vascular resistance, and decreases filling pressure in the heart. Natriuretic peptides have emerged as important diagnostic tools that have generated interest in finding broader applications for their use. The purpose of this review is to discuss the clinical approaches and future applications of natriuretic peptides in diagnosing of heart diseases in dogs and cats.
Keywords:
cats, cardiovascular diseases, heart diseases, dogs, diagnostic techniques, diagnosis,
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- ISSN: 1017-8422
- Yayın Aralığı: Yılda 3 Sayı
- Başlangıç: 1990
- Yayıncı: Yüzüncü Yıl Üniv. Veteriner Fak.
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