Sezgin OKÇELİK, Mevlüt GÖK, İrfan ŞENER, FERHAT ATEŞ, HASAN SOYDAN, ÖMER YILMAZ, Temuçin ŞENKUL

Varikosel ile ortalama platelet hacmi arasındaki bağlantı hala açık değil

Giriş: Bu çalışmada varikosel ile ortalama platelet hacmi arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Üroloji polikliniğine kontrol amacıyla başvuran hastalar çalışmaya dahil edildi. Bütün hastaların fizik muayeneleri aynı üroloji uzmanı tarafından yapıldı. Periferik venöz kan örnekleri aç karnına saat 8:30 ile 12:00 arasında alındı. Tam Kan analizi kan alındıktan 2 saat içinde Mindray BC 5500 Auto Hematology Analyzer( (Mind-ray Bio-Medical Electronics Co., Ltd., Shenzhen, China) cihazı ile yapıldı. Hastalar iki gruba ayrıldı. Grup 1: Grade III varikosel grubu; Grup 2: Kontrol grubu. Hastaların yaşları, RBC, Hb, MCV ,WBC, PLT, MPV değerleri kaydedildi. İstatistiksel analiz SPSS for windows ver. 16.0 (SPSS Inc., Chicago, IL, USA) kullanılarak yapıldı. İstatistiksel anlamlılık p < 0.05 olarak kabul edildi. Bulgular: Ekim 2014 ile Mart 2015 tarihleri arasında 309 hasta çalışmaya dahil edildi. Ortalama yaş 22.94±1.71, ortalama RBC 5.29±0.43, ortalama Hb 16.21±1.03, ortalama MCV 91.01±5.96, ortalama WBC 6.97±1.76, ortalama PLT 248.01±56.76, ortalama MPV 10.89±6.40 idi. 144 hastada grade III varikosel ve 165 hastada normal fizik muayene bulguları mevcuttu. Her iki grubun yaşları benzerdi. RBC, Hb, MCV, WBC değerleri her iki grup arasında farklı değildi. Platelet değerleri varikosel grubunda anlamlı şekilde düşüktü. MPV değerleri varikosel grubunda yüksekti, fakat bu istatistiksel olarak anlamlı değildi. Sonuç: Ortalama platelet hacmi varikosel grubunda yüksek olmasına rağmen istatistiksel olarak anlamlı değildi. Buna bağlı olarak ortalama platelet hacmi varikoselin patofizyolojisi ile ilgili olmayabilir.

The relationship between varicocele and mean platelet volume levels is still not clear

Objective: To assess the relationship between mean platelet volume levels and varicocele.Materials and Methods: Patients, who admitted to urology outpatient clinic for check-up, enrolled in the study. All physical examinations were made by a single urologist. Peripheral venous blood samples were collected to tube including ethylenediaminetetraacetic acid (EDTA-K2) anticoagulant between 8:30 AM and 12 AM after an overnight fasting. All complete blood count (CBC) analysis done within 2 hours after venipuncture using Mindray BC 5500 Auto Hematology Analyzer (Mind-ray Bio-Medical Electronics Co., Ltd., Shenzhen, China). Patients were divided into two groups. Group 1: Grade III varicocele group; Group 2: Control group. We recorded the patient's age, red blood cell (RBC), hemoglobin (Hb), mean corpuscular volume (MCV), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV) values.Statistical analyses were per formed using the SPSS for windows ver. 16.0 (SPSS Inc., Chicago, IL, USA). Statistical significance was set at p < 0.05.Results: Three hundered and nine patients enrolled in the study between September 2014 and March 2015. Mean age was 22.94±1.71, mean RBC was 5.29±0.43, mean Hb was 16.21±1.03, mean MCV was 91.01±5.96, mean WBC was 6.97±1.76, mean PLT was 248.01±56.76, mean MPV was 10.89±6.40. 144 patients had grade III varicocele and 165 patients had normal physical examination. Age of two groups were similar. There was not any significant difference for RBC, Hb, MCV, WBC levels between two groups. Platelet levels were significantly low in varicocele group. MPV levels were high in varicocele group, but it was not statistically significant.Conclusions: Although mean platelet volumes high in varicocele group, it was not statistically significant. According to that mean platelet volume may not be related to the physiopathology of varicocele.

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1. Baazeem A, Belzile E, Ciampi A, et al. Varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. Eur Urol 2011;60:796-808.
2. Redmon JB, Carey P, Pryor JL. Varicocele: the most com- mon cause of male factor infertility? Hum Reprod Update 2002;8:53-8.
3. Inci K, Gunay LM. The role of varicocele treatment in the management of non-obstructive azoospermia. Clinics 2013;68:89-98.
4. Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996;7:157-61.
5. Coban S, Keles I, Biyik I et al. Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels? Can Urol Assoc J 2015;9:E5-9.
6. Coban S, Keles I, Bıyık I, et al. Is there any relationship be- tween mean platelet volume and varicocele? Andrologia 2014;47:37–41.
7. Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascu- lar diseases. Int J Clin Pract 2009;63:1509-15.
8. Lancé MD, van Oerle R, Henskens YM, et al. Do we need time adjusted mean platelet volume measurements? Lab Hematol. 2010;16:28-31.
9. Mahdavi-Zafarghandi R, Shakiba B, Keramati MR, et al. M. 19 Yeni Üroloji Dergisi - The New Journal of Urology 2017; 12 (2): 17-20 Platelet volume indices in patients with varicocele.” Clini-cal and experimental reproductive medicine 2014;41: 92-95.
10. Bozkurt Y, Soylemez H, Sancaktutar AA, et al. Relationship between mean platelet volume and varicocele: a preliminary study. Urology 2012;79:1048-51.
11. Beyan C, Beyan E. Mean platelet volume may not be re-lated to the physiopathology of varicocele. Androlo-gia 2015;47:367.
12. Leader A, Pereg D, Lishner M. Are platelet volume in-14. De Luca G, Verdoia M, Cassetti E, et al. Novara Atheroscle- rosis Study (NAS) group Mean platelet volume is not as- sociated with platelet reactivity and the extent of coronary artery disease in diabetic patients. Blood Coagul Fibrinoly- sis 2013; 24:619–624.
13. Nena E, Papanas N, Steiropoulos P, et al. Mean Platelet Vol-ume and Platelet Distribution Width in non-diabetic sub- jects with obstructive sleep apnoea syndrome: new indices of severity? Platelets 2012;23:447–454.
14. De Luca G, Verdoia M, Cassetti E, et al. Novara Atheroscle- rosis Study (NAS) group Mean platelet volume is not as- sociated with platelet reactivity and the extent of coronary artery disease in diabetic patients. Blood Coagul Fibrinoly- sis 2013; 24:619–624.
15. Beyan C, Kaptan K, Ifran A. Platelet count, mean plate- let volume, platelet distribution width, and plateletcrit do not correlate with optical platelet aggregation responses in healthy volunteers. J Thromb Thrombolysis 2006;22:161–dices of clinical use? A multidisciplinary review.Ann 164.Med 2012;44:805–816.
16. Camoglio FS, Peretti M, Bianchi F, et al. Mean platelet vol- ume and varicocele: comparison between adolescents and adults. Am J Clin Exp Urol 2015;3:100-106.