Amir NASERİ, İsmail ŞEN, Kürşat TURGUT, Hasan GUZELBEKTES

Doğal Gelişen Şiddetli Sepsisli ve Septik Şoklu Buzağılarda Pıhtılaşma Bozuklukları ve Kardiyak Biyomarkırlarının Değerlendirilmesi

Sepsis sırasında pıhtılaşma anormallikleri ve miyokardiyal hasarı sıklıkla ortaya çıkmaktadır. Bu çalışmanın amacı septik neonatal buzağılarda pıhtılaşma parametrelerini ve kardiyak spesifik biyobelirteçleri belirlenen aralıklarla değerlendirmekti. 20 adet sepsisli buzağı ve 10 adet sağlıklı buzağı dahil edildi. Pıhtılaşma parametreleri için prothrombin zamanı (PT), active edilmiş parsiyel tromboplastin zamanı (APTT), D-dimer, fibrinojen, antitrombin III (AT III), trombosit ve kardiyak biyobelirteçler için kardiyak troponin (cTn) I, T ve kreatin kinaz-MB (CK-MB) sepsisli buzağılarda tedavi öncesi, 24. ve 72. saatlerinde iki sefer ve sağlıklı buzağılarda tek sefer olarak değerlendirildi. Pıhtılaşma parametrelerinin sonuçları, PT ve APTT sürelerinde tedavi öncesinden 72. saate kadar önemli bir artış ve AT III ve fibrinojende tedavi öncesinden 72. saate kadar önemli biraz azalma belirlendi. Sepsisli buzağılarda kardiyak troponin T ve CK-MB 72 saatte anlamlı olarak yükseldiği tespit edildi. PT, APTT, fibrinojen ile kardiyak troponin T arasında korelasyon olduğu belirlendi. Sonuç olarak, kardiyak hasar, yaygın damar için pıhtılaşmanın (YDP) hiperkoagülasyon aşamasında gelişebilir ve bu durum cTn T ve CK-MB yükselmesine ve prognozun kötü olmasına yol açabilmektedir.

Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock

Coagulation abnormalities and myocardial injury frequently occur during sepsis. The aim of the present study was to evaluate the coagulation parameters and cardiac-specific biomarkers at set intervals in septic neonatal calves. Ten healthy calves and 20 septic calves were included in the study. For detecting coagulation parameters prothrombin time (PT), activated partial thromboplastin time (APTT), D-dimer, fibrinogen, antithrombin III (AT III), thrombocyte and, for cardiac biomarkers cardiac troponin (cTn) I, T, and creatine kinase-MB (CK-MB) were evaluated on admission, 24 and 72 hours later in septic calves and once in healthy calves. The results of coagulation parameters showed a significant elevation of PT and APTT times from the time of admission until the 72nd hour and a significant reduction of AT III and fibrinogen from the time of admission until the 72nd hour. Cardiac troponin T was high in the 72nd hour, and CK-MB was high in the time of admission, 24th and 72nd hours in septic calves compare to the healthy calves. There was a correlation between PT, APTT, fibrinogen with cardiac troponin T. In conclusion, cardiac damage can develop during the hypercoagulable state of disseminated intravascular coagulation (DIC), and maybe it is responsible for the elevation of cTnT and CK-MB and worse outcome in neonatal septic calves.

Keywords:

sepsis, Biomarker, Disseminated intravascular coagulation, Myocardium,

Tam Metin

Kaynakça

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Kaynak Göster

Bibtex	@araştırma makalesi { vanvetj855449, journal = {Van Veterinary Journal}, issn = {2149-3359}, eissn = {2149-8644}, address = {YYÜ Veteriner Fakültesi Dergi Editörlüğü Kampüs Van Turkey}, publisher = {Yüzüncü Yıl Üniversitesi}, year = {2021}, volume = {32}, pages = {28 - 32}, doi = {10.36483/vanvetj.855449}, title = {Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock}, key = {cite}, author = {Naseri, Amir and Şen, İsmail and Turgut, Kürşat and Guzelbektes, Hasan} }
APA	Naseri, A , Şen, İ , Turgut, K , Guzelbektes, H . (2021). Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock . Van Veterinary Journal , 32 (1) , 28-32 . DOI: 10.36483/vanvetj.855449
MLA	Naseri, A , Şen, İ , Turgut, K , Guzelbektes, H . "Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock" . Van Veterinary Journal 32 (2021 ): 28-32 <https://dergipark.org.tr/tr/pub/vanvetj/issue/60883/855449>
Chicago	Naseri, A , Şen, İ , Turgut, K , Guzelbektes, H . "Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock". Van Veterinary Journal 32 (2021 ): 28-32
RIS	TY - JOUR T1 - Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock AU - Amir Naseri , İsmail Şen , Kürşat Turgut , Hasan Guzelbektes Y1 - 2021 PY - 2021 N1 - doi: 10.36483/vanvetj.855449 DO - 10.36483/vanvetj.855449 T2 - Van Veterinary Journal JF - Journal JO - JOR SP - 28 EP - 32 VL - 32 IS - 1 SN - 2149-3359-2149-8644 M3 - doi: 10.36483/vanvetj.855449 UR - https://doi.org/10.36483/vanvetj.855449 Y2 - 2021 ER -
EndNote	%0 Van Veterinary Journal Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock %A Amir Naseri , İsmail Şen , Kürşat Turgut , Hasan Guzelbektes %T Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock %D 2021 %J Van Veterinary Journal %P 2149-3359-2149-8644 %V 32 %N 1 %R doi: 10.36483/vanvetj.855449 %U 10.36483/vanvetj.855449
ISNAD	Naseri, Amir , Şen, İsmail , Turgut, Kürşat , Guzelbektes, Hasan . "Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock". Van Veterinary Journal 32 / 1 (Mart 2021): 28-32 . https://doi.org/10.36483/vanvetj.855449
AMA	Naseri A , Şen İ , Turgut K , Guzelbektes H . Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock. Van Vet J. 2021; 32(1): 28-32.
Vancouver	Naseri A , Şen İ , Turgut K , Guzelbektes H . Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock. Van Veterinary Journal. 2021; 32(1): 28-32.
IEEE	A. Naseri , İ. Şen , K. Turgut ve H. Guzelbektes , "Evaluation of Coagulation Abnormalities and Cardiac Biomarkers in Calves with Naturally Occurring Severe Sepsis or Septic Shock", Van Veterinary Journal, c. 32, sayı. 1, ss. 28-32, Mar. 2021, doi:10.36483/vanvetj.855449