Ersoy ÖKSÜZ, M. Serdar BUĞDAY, Leman ACUN DELEN, Ozlem ÇAĞAŞAR, Bilgehan DEMİR, İbrahim AKTAŞ, Muhammet SİANANOĞLU, Ayşegül ALTINTOP GEÇKİL, Rabia AYDOGAN BAYKARA, Hülya ALADAĞ, Ajda GÜNEŞ, Erdal AKTÜRK, İrem PEMBEGÜL

Covid 19: Risk faktörleri, Tedavide Kullanılan İlaçlar ve Ölüm Oranı

Amaç: Corona Virüs 19’un neden olduğu hastalık, 2019 yılının sonunda ortaya çıkan halen Dünya genelinde yaygın olarak görülen pandemik hastalıktır. Hafif vakalarda klasik bir üst solunum enfeksiyonu şeklinde seyretse de ağır vakalarda pnömoni ve solumun sıkıntısına yol açarak ölüme neden olur. Günümüzde halan spesifik bir ilaç tedavisi bulunmamakta ve çeşitli ilaçlar tedavi için denenmektedir. Bu çalışmada, Corona Virüs 19’a yakalanan hastaların demografik özellikleri, risk faktörleri, kullanılan ilaçlar ve bu ilaçların mortalite üzerine etkilerinin araştırılması amaçlandı. Materyal ve Metot: Malatya Eğitim ve Araştırma Hastanesi’nde 2020 yılı Mart-Mayıs ayları arasında Covid 19 tanısı ile yatan ve test sonucu pozitif olan toplam 71 hasta, hastanenin veri tabanından ve Halk Sağlığı Yönetim Sisteminden retrospektif olarak taranarak kaydedildi. Bu hastaların, demografik özellikleri, yattıkları servis, yatış süreleri, ek hastalıkları, sağ kalım durumları, kullandıkları ilaçlar tespit edildi. İstatiksel analiz için SPSS (IBM SPSS for Windows, ver.24) ve Minitab (Statistical Software for Windows, ver.17) istatistik paket programları kullanılmıştır. Bulgular: Erkek hastaların sayısı kadınlara göre istatiksel anlamlı olarak yüksekti (p:0,001). Ölüm oranı erkeklerde kadınlara göre daha yüksekti (p:0,001). Hastaların 73%’de en az bir ek hastalık vardı. En fazla görülen ek hastalık hipertansiyondu (48%). Ek hastalığı olan hastaların ölüm oranı olmayanlara göre istatiksel anlamlı olarak yüksekti (p:0,001). Hastanemizde Covid 19’a karşı rutin olarak hidroksiklorokin, oseltamivir, azitromisin, favipiravir, ritonavir ve lopinavir olmak üzere beş ilaç grubu kullanılmıştı. Bu ilaçlar içerisinden en fazla kullanılan hidroksiklorokin’di (77%). Kullanılan ilaçların mortalite üzerine herhangi bir etkisi yoktu (p:0582). Sonuç: Çalışmamızın sonuçları, Covid 19 hastalığına yakalananların çoğunluğunun erkek olduğunu, yaşın önemli bir risk faktörü olduğunu, ek hastalıkların mortalite riskini artırdığını, kullanılan bütün ilaçların mortalite üzerinde herhangi bir etkisinin olmadığını göstermektedir.

Anahtar Kelimeler:

covid 19, Favipiravir, Hidoksiklorokin

COVID 19: Risk factors, Drugs Used in Treatment and Mortality Rate

Objective: The disease caused by Coronavirus 19 is a pandemic disease that emerged at the end of 2019 and has spread worldwide. Although it progresses as a classical upper respiratory tract infection in mild cases, it causes death by causing pneumonia and respiratory distress in severe cases. Although various drugs have been tried, there is still no specific drug treatment. The aim of this study is to investigate the demographic characteristics, risk factors, drugs used and the effects of these drugs on mortality of patients who were infected with Coronavirus 19. Materials and Methods: A total of 71 patients hospitalized in Malatya Training and Research Hospital with the diagnosis of COVID-19 due to positive test results between March 2020 and May 2020 were retrospectively rewieved and recorded from the hospital's database and the Public Health Management System. The demographic characteristics of these patients, the service they were hospitalized, the duration of hospitalization, additional diseases, survival status, and the drugs they used were recorded. statistical analyses were performed by using SPSS (IBM SPSS for Windows, ver.24) and Minitab (Statistical Software for Windows, ver.17) statistical package programs. Results: The number of male patients was statistically significantly higher than female patients (p: 0.001). Mortality rate was higher in males than females (p: 0.001). 73% of the patients had at least one additional disease. The most common additional disease was hypertension (48%). The mortality rate of patients with comorbidities was statistically significantly higher than those without (p: 0.001). In our institution 5 drug groups, including hydroxychloroquine, oseltamivir, azithromycin, favipiravir, ritonavir and lopinavir have been were routinely used against COVID-19. The most frequently used drug was hydroxychloroquine (77%). The drugs used had no effect on mortality (p: 0582). Conclusion: The results of our study indicate that the majority of those who get COVID 19 are men, age is an important risk factor, additional diseases increase the risk of mortality, and all the drugs used have no effect on mortality.

Keywords:

COVID 19, favipiravir, hydroxychloroquine,

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