Adil Ömer KARAKUŞ, Sevim KASAP, Hüseyin DÜLGER, Ethem Mutlu TEMİZEL

Neonatal Ruminantlarda D-laktik Asidoz

Neonatal ruminantlarda D-laktik asidoz, metabolik asidoza sebep olan ve sıklıkla gözden kaçabilen bir durumdur. D-laktik asidoz ile seyreden hastalıklar hayvan türlerine göre farklı isimlerle adlandırılmıştır. Oğlaklarda hastalık tablosu ‘Floppy Kid Disease’, sığırlarda ‘Ruminal Drinkers’ son olarak kuzularda ‘Drunken Lamb Sendromu’ olarak adlandırılmıştır. Bu üç hastalığın etiyopatogenezinde, rumende veya barsak florasında ani ve çok miktarda bakteriyel fermantasyon sonucu artan D-laktik asit’in sistemik dolaşıma katılması ve anyon açıklı metabolik asidozun oluşumu rol almaktadır. D-laktik asidoz, depresyon, dehidrasyon ve nörolojik belirtilerin oluşmasına yol açabilmekte ve tanısı zor konulmaktadır. Bu derlemede D-laktik asidoz’un metabolizması, patogenezi hayvan türlerine göre oluşan klinik bulguları ve laboratuvar değişimleri irdelenecektir.

D-lactic Acidosis in Neonatal Ruminants

D-lactic acidosis in neonatal ruminants is a condition that causes metabolic acidosis and is often overlooked. D-lactic acidosis-related diseases are named differently according to animal species. The disease is called 'Floppy Kid Disease' in goat kids, 'Ruminal Drinkers' in cattle, and 'Drunken Lamb Syndrome' in lambs. Large quantities of D-lactic acid is produced by bacterial fermantation in colon and rumen and absorbed through intestines, thus anion-gap metabolic acidosis occur. D-lactic acidosis can cause depression, dehydration and neurological symptoms therefore diagnoses can be challenging. In this review, metabolism, pathogenesis, clinical manifestations and laboratory alterations of D-lactic acidosis will be evaluated.

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