CENK AYDIN, Engin KENNERMAN, NURTEN GALİP, Murat YALÇIN, Füsun AK, Cüneyt KAYAALP

Hepatik iskemi-reperfüzyon hasarının sıçanlarda alyuvar ve plazma elektrolit dengesi, bazı serum biyokimyasal parametreleri ve karaciğer hücre histolojisi üzerine etkisi

Bu çalışmada parsiyel hepatik iskemi-reperfüzyon hasarının alyuvar ve plazma elektrolit dengesi, bazı serum biyokimyasal parametreleri ve karaciğer hücre histolojisi üzerine etkisi değerlendirildi. Karaciğerin sol ve orta loplarına ait A. hepatica, V. porta damarları ile safra kanalını içeren hepatik pedikül bağlanarak 60 dakika iskemi etkisine bırakıldı. Otuz dakikalık reperfüzyon sonrası, değerlendirme için kan ve karaciğer doku örnekleri alındı. İskemi-reperfüzyon hasarı serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) değerlerinde artışa (p

Anahtar Kelimeler:

alyuvarlar, potasyum, doku bilimi, karaciğer hücreleri, karaciğer, aspartat aminotransferaz, kan kimyası, alanin aminotransferaz, sıçan, sodyum, iskemi, elektrolitler

Effect of partial hepatic ischemic-reperfusion injury on erythrocyte and plasma electrolyte balance, some serum biochemical parameters and liver cell histology in rats

In this study, the effects of partial hepatic ischemia reperfusion injury on erythrocyte and plasma electrolyte balance, some serum biochemical parameters and liver cell histology were evaluated. Liver were subjected to 60 min of partial warm ischemia by clamping the hepatic pedicle which includes the A. hepatica, V. portae vessels and bile duct of the left and middle liver lobes. After 30 minutes reperfusion, blood samples and liver specimens were taken for evaluation. Ischemia-reperfusjon injury induced increased (p<0.001) serum Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) and decreased (p<0.05) plasma sodium (PNa) level and changes in hepatocyte histology. It was concluded that partial hepatic ischemia-reperfusion injury which causes severe hepato-cellular dysfunction induces changes also in the erythrocyte and plasma electrolyte balance.

Keywords:

erythrocytes, potassium, histology, liver cells, liver, aspartate aminotransferase, blood chemistry, alanine aminotransferase, rats, sodium, ischaemia, electrolytes,

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