Treatment of hypersexuality and benign prostatic hypertrophy with delmadinone acetate in intact male dogs

The aim of the present study was to evaluate the effectiveness of delmadinone acetate (DMA) for the treatment of hypersexuality (HS) and benign prostatic hypertrophy (BPH), which are frequently observed in male dogs, for which no surgical treatment has been indicated. The study was performed with 21 intact male dogs that had HS (n = 12) and signs of BPH (n = 9). DMA (Tardak® or Tardastrex®) was administered subcutaneously to each dog at a dose of 3-5 mg/kg and was repeated 15 days later as a second treatment. DMA administration was repeated in some cases until the clinical signs disappeared. The successful recovery rate of HS cases was found to be 50% after a single application and 25% by the second and third applications. The mean "recovery periods" and mean "stable periods" of these 3 consecutive applications were found to be 5.83, 7.66, and 6.00 days, and 16.7, 18.7, and 20.0 months, respectively. With regard to BPH after consecutive applications, treatment success rates, mean recovery periods, and mean stable periods were 33.3%, 22.2%, 44.4%, 12.0, 11.0, 9.5 days, and >30, 12, and 13.5 months, respectively. DMA is clinically applicable as a therapeutic agent for HS and BPH cases; however, repeated applications were required due to temporary recoveries.

Treatment of hypersexuality and benign prostatic hypertrophy with delmadinone acetate in intact male dogs

The aim of the present study was to evaluate the effectiveness of delmadinone acetate (DMA) for the treatment of hypersexuality (HS) and benign prostatic hypertrophy (BPH), which are frequently observed in male dogs, for which no surgical treatment has been indicated. The study was performed with 21 intact male dogs that had HS (n = 12) and signs of BPH (n = 9). DMA (Tardak® or Tardastrex®) was administered subcutaneously to each dog at a dose of 3-5 mg/kg and was repeated 15 days later as a second treatment. DMA administration was repeated in some cases until the clinical signs disappeared. The successful recovery rate of HS cases was found to be 50% after a single application and 25% by the second and third applications. The mean "recovery periods" and mean "stable periods" of these 3 consecutive applications were found to be 5.83, 7.66, and 6.00 days, and 16.7, 18.7, and 20.0 months, respectively. With regard to BPH after consecutive applications, treatment success rates, mean recovery periods, and mean stable periods were 33.3%, 22.2%, 44.4%, 12.0, 11.0, 9.5 days, and >30, 12, and 13.5 months, respectively. DMA is clinically applicable as a therapeutic agent for HS and BPH cases; however, repeated applications were required due to temporary recoveries.

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  • Arbeiter, K.: Anwendung von Hormonen in der Reproduktion von Hund und Katze. In: Döcke, F., Ed. Veterinärmedizinische Endokrinologie. 3. Auflage, Gustav Fischer Verlag, Jena, Stutgart. 1994; 823-841.
  • Holzmann, A.: Pathologie der akzessorischen Drüsen. In: Busch, W., Holzmann, A., Eds. Veterinaermedizinische Andrologie. Schattauerverlag, Stuttgart. 2001; 423-427.
  • Lange, K., Cordes, E.K., Hoppen, H.O., Günzel-Apel, A.R.: Determination of concentrations of sex steroids in blood plasma and semen of male dogs treated with delmadinone acetate or finasteride. J. Reprod. Fertil. (Suppl.), 2001; 57: 83-91. 8. Feeney, D.A., Johnston, G.R., Klausner, J.S.: Two-dimensional, gray-scale ultrasonography. Applications in canine prostatic disease. Vet. Clin. North Am. Small Anim. Pract., 1985; 15: 1159-1176.
  • Lamb, C.R.: Abdominal ultrasonography in small animals: intestinal tract and mesentery, kidneys adrenal glands, uterus and prostate. J. Small Anim. Pract., 1990; 31: 295-304.
  • Tsutsui, T., Hori, T., Shimizu, M., Orima, H., Kawakami, E., Fukuda, S.: Regression of prostatic hypertrophy by osaterone acetate in dogs. J. Vet. Med. Sci., 2000; 62: 1115-1119.
  • Anderson, A., Linde-Forsberg, C.: Castration and progestagen treatment of male dogs, part 1. Eur. J. Compan. Anim. Pract., 2002; 12:173-177
  • Court, E.A., Watson, A.D.J., Church, D.B., Emslie, D.R.: Effect of delmadinone acetate on pituitary-adrenal function, glucose tolerance and growth hormone in male dogs. Aust. Vet. J., 1998; 76: 555-560.
  • Arbeiter, K.: Diseases of the prostate in the dog. Tierärztl. Prax., 1987; 15: 291-294. (article in German with an abstract in English)
  • Kamolpatana, K., Johnston, G.R., Johnston, S.D.: Determination of canine prostatic volume using transabdominal ultrasonography. Vet. Radiol. Ultrasound, 2000; 41: 73-77.
  • Finn, S.T., Wrigley, R.H.: Ultrasonography and ultrasound- guided biopsy of the canine prostate. In: Kirk, R.W., Bonagura, J.D. Eds., Current Veterinary Therapy X: Small Animal Practice. W. B. Saunders, Philadelphia. 1989; 1227-1239.
  • Paclikova, K., Kohout, P., Vlasin, M.: Diagnostic possibilities in the management of canine prostatic disorders. Vet. Med.-Czech, 2006; 51: 1-13.
  • Papanicolau, G.N.: A new procedure for staining vaginal smears. Science, 1942; 95: 438-439.
  • Holzmann, V.A.: Hypersexualität beim Rüden. Wien. Tierärztl. Monat., 1975; 62: 355-356.
  • Leidl, W.: Fortpflanzungsstörungen bei Hund und Katze. In: Schaetz, F., Leidl, W., Eds. Fortpflanzungsstörungen bei den Haustieren. Ferdinand Enke Verlag, Stuttgart. 1983; 354-376.
  • Juniewicz, P.E., Barbolt, T.A., Egy, M.A., Frenette, G., Dube, J.Y., Tremblay, R.R.: Effects of androgen and antiandrogen treatment on canine prostatic arginine esterase. Prostate, 1990; 17: 101- 111.
  • Berry, S.J., Coffey, D.S., Strandberg, J.D., Ewing, L.L.: Effect of age, castration and testosterone replacement on the development and restoration of canine benign prostatic hyperplasia. Prostate, 1986; 9: 295-302.
  • Forbes, L.: An ultrasonographic study of the effect of age, bodyweight and castration on the size of the canine prostate gland. London, Univ., B. Vet. Med., Dissertation, 1992.
  • Cain, J.L.: Drugs used to treat reproductive disorders. Vet. Clin. North Am. Small Anim. Pract., 1998; 28: 395-410.
  • Allen, W.E., England, G.C.W.: Endokrinologie der Fortpflanzung beim Rüden, In: Hutchison, M., Ed. Kompendium der Endokrinologie- Hund und Katze, Schlütersche Verlagsanstalt, Hannover. 1996; 119-123.
Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
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