Antagonism of Medetomidine Sedation in Goats by Atipamezole and Yohimbine

The alpha 2-adrenoceptor antagonists atipamezole and yohimbine were used to antagonize medetomidine-induced sedation in 6-8-month-old native breed female goats. Intramuscular injection of medetomidine at the dose rate of 40 m g/kg body weight induced sedation and recumbency within 10-20 min in the goats. After recumbency, the goats were injected with saline (5 ml) (control group), atipamezole (0.2 mg/kg), or yohimbine (0.2 mg/kg) via the jugular vein. The duration of recumbency in the control group was 90 ± 9 min (mean ± SE). The effects of sedation continued in the control group goats even after regaining the righting reflex and standing. Atipamezole and yohimbine significantly reduced the recumbency period to 2 ± 1 and 45 ± 8 min, respectively, in comparison to the control group. The signs of arousal consisted of head raising, assuming sternal recumbency, and standing within 1 min in the atipamezole group and within 15-20 min in the yohimbine group. In contrast to the control group, the atipamezole- and yohimbine-treated goats appeared alert after standing. Atipamezole significantly, but partially reversed medetomidine-induced reductions in heart rate and ruminal contractions, whereas yohimbine partially reversed the medetomidine-induced decrease in heart rate only. The data suggest that atipamezole is useful for antagonizing the central nervous system depressant effects of medetomidine in goats. Atipamezole was also superior to yohimbine as a medetomidine antagonist.

Antagonism of Medetomidine Sedation in Goats by Atipamezole and Yohimbine

The alpha 2-adrenoceptor antagonists atipamezole and yohimbine were used to antagonize medetomidine-induced sedation in 6-8-month-old native breed female goats. Intramuscular injection of medetomidine at the dose rate of 40 m g/kg body weight induced sedation and recumbency within 10-20 min in the goats. After recumbency, the goats were injected with saline (5 ml) (control group), atipamezole (0.2 mg/kg), or yohimbine (0.2 mg/kg) via the jugular vein. The duration of recumbency in the control group was 90 ± 9 min (mean ± SE). The effects of sedation continued in the control group goats even after regaining the righting reflex and standing. Atipamezole and yohimbine significantly reduced the recumbency period to 2 ± 1 and 45 ± 8 min, respectively, in comparison to the control group. The signs of arousal consisted of head raising, assuming sternal recumbency, and standing within 1 min in the atipamezole group and within 15-20 min in the yohimbine group. In contrast to the control group, the atipamezole- and yohimbine-treated goats appeared alert after standing. Atipamezole significantly, but partially reversed medetomidine-induced reductions in heart rate and ruminal contractions, whereas yohimbine partially reversed the medetomidine-induced decrease in heart rate only. The data suggest that atipamezole is useful for antagonizing the central nervous system depressant effects of medetomidine in goats. Atipamezole was also superior to yohimbine as a medetomidine antagonist.
Turkish Journal of Veterinary and Animal Sciences-Cover
  • ISSN: 1300-0128
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Disseminated Streptococcus equi subsp. zooepidemicus ınfection in a foal and associated mastitis in a Mare

Esra BÜYÜKCANGAZ, Cüneyt ÖZAKIN, Ahmet AKKOÇ, A Levent KOCABIYIK, İ. Taci CANGÜL

The effect of duration of finishing period on the performance, slaughter, carcass, and beef quality characteristics of Eastern Anatolian red bulls

Muhlis MACİT, Sinan KOPUZLU, Abdülkadir ÖZLÜTÜRK, Necdet ÜNLÜ, Mete YANAR, Nurinisa ESENBUĞA

Effect of Low Temperature Thawing on the Motility and Fertility of Cryopreserved Water Buffalo and Zebu Bull Semen

Muhammad ANWAR, Sayed Murtaza Hassan ANDRABI, Abid MEHMOOD

Heliotropium dolosum, Heliotropium circinatum ve Senecio vernalis’in Ebeveyn ve Yavru Bıldırcınlarda Toksik Etkileri ve Yumurtada Pirolizidine Alkaloit Kalıntıları

Yesari ERÖKSÜZ, Ali Osman ÇERİBAŞI, Aydın ÇEVİK, Hatice ERÖKSÜZ

Burdur, Konya ve Kırklareli İlleri’ndeki Süt Sığırcılık İşletmelerinde Endemik Hastalıkların İnsidensi

Cengiz YALÇIN, Savaş SARIÖZKAN, Ahmet Şener YILDIZ, Aytekin GÜNLÜ

Morphology and Arterial Vasculature of Donkey (Equus asinus L.) Adrenal Gland

Emine KARAKURUM, Özcan ÖZGEL, Nejdet DURSUN

Cryosurgical Treatment of Anal Sac Fistulae in Dogs

Mehmet SAĞLAM, Ümit KAYA

Seroprevalence of Coxiella burnetii in Stray Cats in Central Anatolia

Selçuk KILIÇ, Tomoyoshi KOMIYA, Bekir ÇELEBİ, Nejat AYDIN, Junko SAITO, Hiroko TORINIWA, Bilge KARATEPE, Cahit BABÜR

Antagonism of Medetomidine Sedation in Goats by Atipamezole and Yohimbine

Mahmood B. MAHMOOD, Fouad K. MOHAMMAD

Disseminated Streptococcus equi subsp. zooepidemicus Infection in a Foal and Associated Mastitis in a Mare

A. Levent KOCABIYIK, Esra BÜYÜKCANGAZ, Ahmet AKKOÇ