Öymen HANÇERLİOĞULLARI, Tutku SOYER, Zuhal AKTUNA, Gökhan OSMANOĞLU, Murat ÖAKMAK, Tolga Reşat AYDOS, Oğuzhan KORKUT

The effect of experimentally induced carbon dioxide pneumoperitoneum on intra-abdominal and intra-esophageal pH

Aim: An experimental study was performed to evaluate the effect of CO2 pneumoperitoneum on intra-abdominal (IA) and intra-esophageal (IE) pH. Material and methods: The study included 18 Wistar rats. In the control group (n = 6) a pH catheter was inserted into the peritoneal cavity via a left upper quadrant incision and another catheter was inserted into the lower esophagus via the oral route. Pre- and post-insufflation IA and IE pH were recorded every 5 min for 1 h. In the experimental groups, in addition to pH catheters, a 16-G catheter was inserted into the abdomen above the umbilicus. In the O2 group (n = 6) 95% O2 and 5% CO2 were insufflated with a pressure of 10 mmHg. In the CO2 group (n = 6), CO2 was insufflated with the same pressure and duration. Results: In the CO2 group, IA and IE pH values significantly decreased (P < 0.05). IA pH values decreased in the CO2 group when compared to the control and O2 groups (P < 0.05). There was not a significant difference in IE pH between the CO2 group and the other groups. Conclusion: CO2 insufflation decreased IA pH values. Decreased pH values obtained with continuous recordings of the esophagus may have been related to increases in intra-abdominal pressure, rather than the metabolic effects of CO2 pneumoperitoneum.

Anahtar Kelimeler:

Key words: Carbon dioxide, pH, pneumoperitoneum, esophagus, abdomen

The effect of experimentally induced carbon dioxide pneumoperitoneum on intra-abdominal and intra-esophageal pH

Keywords:

Key words: Carbon dioxide, pH, pneumoperitoneum, esophagus, abdomen,

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Takada M, Fukumoto S, Ichihara T, Ku Y, Kuroda Y. Comparison of intestinal transit recovery between laparoscopic and open surgery using rat model. Surg Endosc 2003; 17: 1237- 40.
Hunter JG, Swanstrom L, Thornburg K. Carbon dioxide pneumoperitoneum induces fatal acidosis in a pregnant ewe model. Surg Endosc 1995; 113: 527-31.
Tournadre JP, Allaouchiche B, Malbert CH, Chassard D. Metabolic acidosis and respiratory acidosis impair gastro- pyloric motility in anesthetized pigs. Anesth Analg 2000; 90: 74-9.
Unsal MA, Imamoglu M, Kadioglu M, Aydin S, Utku C, Kesim M et al. The acute alterations in biochemistry, morphology, and contractility of rat-isolated terminal ileum via increased intra- abdominal pressure. Pharmacological Research 2006, 53: 135- 41.
Hanly EJ, Aurora AR, Fuentes JM, Shih SP, Marohn MR, De Maio A et al. Abdominal insufflation with CO2 causes peritoneal acidosis independent of systemic pH. J Gastrointest Surg 2005; 9: 1245-52.
Chassard D, Berrada KR, Tournadre JP, Boulétreau P. The effect of increased in end tidal carbon dioxide on lower esophageal sphincter tone. Anesth Analg 1996; 82: 374-6.