An analysis of adult patients with pulmonary and extrapulmonary tuberculosis*

Aim: In this study, it was planned to compare the features of pulmonary and extra-pulmonary tuberculosis patients over age 15 years. Materials and methods: We compared 360 newly diagnosed pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) patients who were treated and followed up in Kahramanlar Tuberculosis Dispensary between 2000 and 2003, and were older than 15 years of age. The medical records of both patient groups were investigated in terms of age, sex, accompanying diseases, contact history and means of diagnosis. Results: The data were compared statistically between the 2 groups. Of these patients 78.1% were diagnosed with PTB while 21.9% were diagnosed with EPTB. The proportion of male patients was 79.3% in the PTB group and 49.4% in the EPTB group (P < 0.0001). According to the medical histories of the patients, the mean duration between the onset of symptoms and diagnosis was 85.75 ± 77.02 (days) in PTB patients and 193.65 ± 340.40 (days) in EPTB patients (P = 0.001). The rates of bacteriological diagnosis of tuberculosis were 95.37% in PTB patients and 5.06% in EPTB patients, which indicated a significantly higher rate of bacteriological diagnosis in PTB patients. Conclusion: There were statistically significant differences between the PT and EPT patients over 15 years, and EPT was found to be associated with female sex, a lower rate of bacteriological diagnosis, and delay in diagnosis.

An analysis of adult patients with pulmonary and extrapulmonary tuberculosis*

Aim: In this study, it was planned to compare the features of pulmonary and extra-pulmonary tuberculosis patients over age 15 years. Materials and methods: We compared 360 newly diagnosed pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) patients who were treated and followed up in Kahramanlar Tuberculosis Dispensary between 2000 and 2003, and were older than 15 years of age. The medical records of both patient groups were investigated in terms of age, sex, accompanying diseases, contact history and means of diagnosis. Results: The data were compared statistically between the 2 groups. Of these patients 78.1% were diagnosed with PTB while 21.9% were diagnosed with EPTB. The proportion of male patients was 79.3% in the PTB group and 49.4% in the EPTB group (P < 0.0001). According to the medical histories of the patients, the mean duration between the onset of symptoms and diagnosis was 85.75 ± 77.02 (days) in PTB patients and 193.65 ± 340.40 (days) in EPTB patients (P = 0.001). The rates of bacteriological diagnosis of tuberculosis were 95.37% in PTB patients and 5.06% in EPTB patients, which indicated a significantly higher rate of bacteriological diagnosis in PTB patients. Conclusion: There were statistically significant differences between the PT and EPT patients over 15 years, and EPT was found to be associated with female sex, a lower rate of bacteriological diagnosis, and delay in diagnosis.

___

  • 1. Dwyer DE, Collignon PJ, Macleod C, Sarrel T. Extrapulmonary tuberculosis. A continuing problem in Australia. August NZJ Med 1987; 17: 507-11.
  • 2. Golden MP, Vikram HR. Extrapulmonary tuberculosis: An overview. Am Fam Physician 2005; 72: 1761-8.
  • 3. WHO. Global Tuberculosis Control. Surveillance, Planning, Financing. Communicable Diseases, World Health Organization Geneva: 2002. WHO/CDC/TB/2002.295
  • 4. Kılıçaslan Z, Öztürk F, Sarımurat N, Cuhadaroğlu C, Çağlar E, Erem A. Microscopic examination and treatment outcomes of new pulmonary tuberculosis cases in İstanbul dispensaries between 1998-2000. Int. J Tuberc Lung Dis 2003; 7: 1059-63.
  • 5. www.verem.org.tr. Accessed 14 April 2007
  • 6. Treatment of tuberculosis Guidelines for National programmes. World Health Organization. Second Edition 1997. WHO/TB/97.220.
  • 7. Styblo K. Epidemiology of tuberculosis. KNVC Royal Netherlands Tuberculosis Association. Selected Papers. The Hague 1991; 24: 3-4.
  • 8. Çağatay AA, Çalışkan Y, Aksoz S, Güleç L, Kucukoğlu S et al. Extrapulmonary tuberculosis in immunocompetent adults. Scand. J Infect Dis 2004; 36: 799-806.
  • 9. Kochi A. The Global Tuberculosis situation and the new control strategy of the World Health Organization. Tubercl 1991; 72: 1- 6.
  • 10. Yoon JH, Sang GY, Park II W, Choi DJ, Chang HK, Kim MJ. Clinical manifestation and diagnosis of extrapulmonary tuberculosis. Yonsei Medical Journal 2004; 45: 453-61
  • 11. Aktoğu S, Yorgancıoğlu A, Çırak K, Köse T, Dereli ŞM. Clinical spectrum of pulmonary and pleural tuberculosis: a report of 5480 cases. Eur Respir J 1996; 9: 2031-5.
  • 12. http://www.who.int/tb/dots/gender/page_1/en/index.html Accessed: 20 April 2007
  • 13. Noertjojo K, Tam CM, Chan SL, Chan-Yeung MM. Extrapulmonary and pulmonary tuberculosis in Hong Kong. Int J Tuberc Lung Dis 2002; 6: 879-86.
  • 14. Pehme L, Hollo V, Rahu M, Altraja A. Tuberculosis during fundamental societal changes in Estonia with special reference to extrapulmonary manifestations. Chest 2005; 127: 1289-95.
  • 15. Namias J, Gambier J. La Tuberculosa a Paris en 1992. Bull Epidemiol Hebdomadaire 1994; 90: 74-5.
  • 16. Martinez NA, Rhee JT, Small PM, Behr AM. Sex differences in the epidemiology of tuberculosis in San Francisco. Int J Tuberc Lung Dis 2000; 4: 26-31.
  • 17. World Health Organization. Global Tuberculosis Programme. Global Tuberculosis Control. WHO Report 1998. WHO/TB/98- 237. Geneva: World Health Organization 1998.
  • 18. Faggiona F, Vigna Taglianti FD, Versino E, Salamina G, Bugiani M. Tuberculosis incidence in Turin, Italy, 1973-79. Int J Tuberc Lung Dis 2004; 8: 1-9.
  • 19. Clark GA, Kelly MA, Grange JM, Cassandra H. The evolution of mycobacterial disease in human populations. A re-evaluation. Current Anthropology 1987; 23: 45-62.
  • 20. Demiralay R. Akciğer ve akciğer dışı organ tüberkülozunun klinik ve epidemiyolojik özelliklerinin karşılaştırılması Tüberküloz ve Toraks Dergisi 2002; 50; 264-71.
  • 21. Musellim B, Erturan S, Sönmez Duman E, Ungen G. Comparison of extra-pulmonary and pulmonary tuberculosis cases: factors influencing the site of reactivation. Int J Tuberc Lung Dis 2005; 10: 1-4.
  • 22. Denis Delpierre N, Merrien D, Billaud E, Besnier JM, Duhamel E, Hutin P. Extrapulmonary tuberculosis in the central Western region retrospective study of 217 cases (Gericco 1991-1993) Pres Med 1998; 27: 341-6.
  • 23. Daley CL. Tuberculosis Latency in Humans. In: Rom WN, Garay SM (Eds) Tuberculosis. Second ed. Philadelphia Lippincott Williams & Wilkins, 2004: 85-9.
  • 24. Perronne C, Saba J, Behloul Z, Salmon-Céron D, Leport C, Vildé JL et al. Pyogenic and tuberculous spondylodiskitis (vertebral osteomyelitis) in 80 adult patients. Clin Infect Dis 1994; 19: 746-50.
  • 25. Simon HB, Weinstein AJ, Pasternak MS, Swartz MN, Kunz LJ. Genitourinary tuberculosis. Clinical features in a general hospital population. Am J Med 1997; 63: 410-20.
  • 26. Bobrowitz ID. Active tuberculosis undiagnosed until autopsy. Am J Med 1982; 72: 650-8.
  • 27. Nolte FS, Beverly M. Mycobacterium. “Murray PR, Baron EJ, Pfaller MA, Tenover FC Yolken RH. (Eds). Manual of Clinical Microbiology. 6th ed. ASM Press Washington. 1995; 400-438.
  • 28. Özşahin SL, Karacan Ö, EL R. Akciğer tüberkülozunda tanıda gecikme. XXI Türk Tüberküloz ve Göğüs Hastalıkları Kongre Kitabı 1996: 317-25.
  • 29. Chakravorty S, Sen MK, Tyagi JS. Diagnosis of extrapulmonary tuberculosis by smear, culture and PCR using universal sample processing technology. J Clin Microbiol 2005; 43: 4357-62.
  • 30. Sharma SK, Mohan A. Extrapulmonary tuberculosis. Indian J Med Res 2004; 120: 316-23.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

The risk factors and spread of multidrug-resistant Acinetobacter baumannii in intubated patients in a medical intensive care unit

Gökhan METAN, Yeşim GÜROL, Mehmet YERER, Sesin KOCAGÖZ, Duygu ESEL, Emine ALP, Mehmet DOĞANAY

Cut-off value of D-dimer in pulmonary thromboembolism and pneumonia

Asiye KANBAY, Ayşegül KARALEZLİ, Selda KAYA, Elif BABAOĞLU, S. Cibali AÇIKGÖZ, H. Canan HASANOĞLU, Derya ÖZTUNA

Anti-HAV seroprevalence in Turkish military personnel and its relation with demographic properties

İsmail Yaşar AVCI, Çakır GÜNEY, CAN Polat EYİGÜN, Hanefi Cem GÜL, Yakup Hakan BAŞARAN, Bülent A. BEŞİRBELLİOĞLU, Ömer COŞKUN, Alaaddin PAHSA, Recai OĞUR, Cengiz Han AÇIKEL

An analysis of adult patients with pulmonary and extrapulmonary tuberculosis

Türkan GÜNAY, Aygün ÖZTOP, İpek ÜNSAL, Avkan Vildan OĞUZ, Rıza ÇAKMAK

Anormal parmakla rektal muayene klinik lokalize prostat kanserli hastalarda yüksek radikal prostatektomi Gleason skorunu (≥7) öngörmede bağımsız bir parametredir

Cüneyt ÖZDEN, Mesut ÇETİNKAYA, Ali MEMİŞ, Özgür UĞURLU, Mehmet YARIŞ, Ç. Volkan ÖZTEKİN, A. Özgür AKDEMİR

Prevalence of Echinococcus granulosus detected using enzyme immunoassay and abdominal ultrasonography in a group of students staying in a state dormitory in Turkey

Metin KORKMAZ, Gülgün DEMİRPOLAT, Sadık TAMSEL, Tansu YAMAZHAN, Hüsnü PULLUKÇU, Oğuz Reşat SİPAHİ, Bilgin ARDAİ

The effects of adding tramadol to ropivacaine on axillary brachial plexus blockade in uremic patients

Mehmet GAMLI, Eyüp HORASANLI, Bayazıt DİKMEN, Dilşen ÖRNEK, Aydın SELÇUK, Melekşah PEKEL

A nationwide survey of prophylaxis against ophthalmia neonatorum in Turkey

Meltem BOZACI, İlker ESER

Management of thyroid cancer associated with elevated serum thyroglobulin and negative radioiodine scanning

Management Of Thyroid Cancer Associated SCANNİNG, Sinan ÇAĞLAYAN, Muammer URHAN, Onur SILDIROĞLU, Yavuz KURT, Mehmet Emin ÖNDE, Yavuz NARİN

An algorithm for the treatment of the biliary complications of hepatic hydatid disease

Bülent AYDINLI, Abdullah KISAOĞLU, Gürkan ÖZTÜRK, M. İlhan YILDIRGAN, K. Yalçın POLAT, Mahmut BAŞOĞLU, Durkaya ÖREN, S. Selçuk ATAMANALP