Skin prick test results and prevalence of allergic symptoms in workers exposed to toluene

To determine the distribution of allergens and allergic symptoms according to occupation groups in those who were exposed to toluene and presented with allergic rhinitis symptoms. Materials and methods: Of the 2005 patients who were administered an allergy test with the prediagnosis of allergic rhinitis, the files of 138 patients who were exposed to toluene were analyzed retrospectively. Results: The mean age of the patients was 35 ± 10 years. Distributions of symptoms and allergens of 57 patients (41.3%) with negative skin prick test and 81 patients (58.7%) with positive skin prick test were analyzed according to occupation groups. There was no significant difference between the groups in terms of symptoms at baseline except for the symptom of runny nose (P > 0.05). The groups were compared in terms of complaints that started at the age of 16 or later, which was found as 76.5% in the positive group and 91.2% in the negative group. Conclusion: The occupation of the patient must be considered in patients who present with allergic symptoms; in particular, patients with negative skin prick test should be investigated in terms of occupational exposure.

Skin prick test results and prevalence of allergic symptoms in workers exposed to toluene

To determine the distribution of allergens and allergic symptoms according to occupation groups in those who were exposed to toluene and presented with allergic rhinitis symptoms. Materials and methods: Of the 2005 patients who were administered an allergy test with the prediagnosis of allergic rhinitis, the files of 138 patients who were exposed to toluene were analyzed retrospectively. Results: The mean age of the patients was 35 ± 10 years. Distributions of symptoms and allergens of 57 patients (41.3%) with negative skin prick test and 81 patients (58.7%) with positive skin prick test were analyzed according to occupation groups. There was no significant difference between the groups in terms of symptoms at baseline except for the symptom of runny nose (P > 0.05). The groups were compared in terms of complaints that started at the age of 16 or later, which was found as 76.5% in the positive group and 91.2% in the negative group. Conclusion: The occupation of the patient must be considered in patients who present with allergic symptoms; in particular, patients with negative skin prick test should be investigated in terms of occupational exposure.

___

  • Schäper C, Gustavus B, Koch B, Ewert R, Hanf G, Kunkel G et al. Eff ects of fexofenadine on inflammatory mediators in nasal lavage fl uid in intermittent allergic rhinitis. J Investig Allergol Clin Immunol 2009; 19: 459-464.
  • Bauchau V, Durham SR. Epidemiological characterization of the intermittent and persistent types of allergic rhinitis. Allergy 2005; 60: 350-3.
  • Nicolaou N, Siddique N, Custovic A. Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy 2005; 60: 1357-60.
  • Agency for Toxic Substances and Disease Registry (ATSDR). Toluene CAS 108-88-3; UN: 1294. Available from: www.atsdr. cdc.gov/MHMI/mmg56.pdf 5. Karabulut I, Balkanci ZD, Pehlivanoglu B, Erdem A, Fadillioglu E. Eff ect of toluene on erythrocyte membrane stability under in vivo and in vitro conditions with assessment of oxidant/ antioxidant status. Toxicol Ind Health 2009; 25: 545-50.
  • Saygun M, Cakmak A, Ekici A, Pinar T, Bulcun E, Ulu N et al. Five annual observations of respiratory fi ndings in gun factory workers exposed to solvents. J Occup Environ Med 2007; 49: 909-12.
  • Polosa R, Al-Delaimy WK, Russo C, Piccillo G, Sarva M. Greater risk of incident asthma cases in adults with allergic rhinitis and eff ect of allergen immunotherapy: a retrospective cohort study. Respir Res 2005; 28: 153.
  • International Rhinitis Working Management Group. International Consensus Report on the diagnosis and management of rhinitis. Allergy 1994; 49 Suppl 9: 5-34.
  • Lund V. Allergic Rhinitis-Making the correct diagnosis. Clin Exp Allergy 1998; 28: 25-8.
  • Karabulut H, Karadağ AS, Acar B, Demir M, Babademez MA, Karaşen RM. Ankara Keçiören bölgesinde deri prick testi sonuçlarının meterolojik ve demografi k özelliklere göre değerlendirilmesi. KBB-Forum 2009; 8: 46-54.
  • Bıçakçı A, Tatlıdil S, Canıtez Y, Malyer H, Sapan N. Mustafakemalpaşa ilçesi (Bursa) atmosferindeki alerjen Alternaria Sp. ve Cladosporium Sp. sporları. Akciğer Arşivi 2001; 2: 69-72.
  • Akgür S, Öztürk P, Kurtulmuş Y, Karali H, Ertürk S. Medicolegal aspects of blood urine toluene and urinary ortho- cresol concentrations in toluene exposure. Turk J Med Sci 2001; 31: 415-419.
  • McGregor D. Th e genetic toxicology of toluene. Mutat Research 1994; 317: 213-228.
  • Tassaneeyakul W, Birkett DJ. Human Cytocrome P450 isoform specifi city in the regioselective metabolism of toluene and o-, m- and p-xylene. J Pharm Exp Th erp 1996; 276: 101-108.
  • Csanady A, Filser JG. Th e relevance of physical activity for the kinetics of inhaled gaseous substances. Arch Toxicol 2001; 74: 663-672.
  • Pierce CH, Dills R, Silvey GW, Kalman DA. Partition coeffi cients between human blood or adipose tissue and air for aromatic solvents. Scand J Work Environ Health 1996; 22: 112- 118.
  • Nomiyama K, Nomiyama H. Respiratory elimination of organic solvents in man. Benzene, toluene, n-hexane, trichloroethylene, acetone, ethyl acetate and ethyl alcohol. Int Arch Arbeitsmed 1974; 32: 85-91.
  • Paustenbach D, Alarie Y, Kule T, Schachter N, Smith R, Swenberg J et al. A recommended occupational exposure limit for formaldehyde based on irritation. Journal of Toxicology and Environmental Health 1997; 50: 217-63.
  • Dutkiewicz T, Tyras H. Th e quantitative estimation of toluene skin absorption in man. Int Arch Arbeitsmed 1968; 24: 253-7.
  • Sato A, Nakajima T, Fujiwara Y, Hirosawa K. Pharmacokinetics of benzene and toluene. International Archives of Occupational and Environmental Health 1974; 33: 169-82.
  • Veulemans H, Masschelein R. Experimental human exposure to toluene. International Archives of Occupational and Environmental Health 1978; 42: 91-103.
  • Andersen I, Lundqvist GR, Molhave L, Pedersen OF, Proctor DF, Vaeth M et al. Human response to controlled levels of toluene in six-hour exposures. Scand J Work Environ Health 1983; 9: 405-18.
  • Baelum J, Andersen IB, Lundqvist GR, Molhave L, Pedersen OF, Vaeth M et al. Response of solvent-exposed printers and unexposed controls to six-hour toluene exposure. Scand J Work Environ Health 1985; 11: 271-80.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

Cutaneous anthrax patients in Eastern Anatolia, Turkey: a review of 44 adults cases

Muhammet Hamidullah UYANIK, Kemalettin ÖZDEN, Serpil EROL, Zülal ÖZKURT, Mehmet PARLAK

Narkolepsili hastalarda omega-3 yağ asit desteğinin plazma oreksin A, plazma yağ asitleri ve antropometrik ölçümlere etkisi

Makbule KARADAĞ GEZMEN, Meral AKSOY

The relationship between symptoms and the results of the skin prick test in patients with allergic rhinitis

Tevfik PINAR, Mehmet Ali BABADEMEZ, Hayriye KARABULUT, Rıza Murat KARAŞEN, Emre GÜNBEY, Baran ACAR, Emrah ÇELİK

Kronik myeloid lösemide imatinibe alınan hematolojik, sitogenetik ve moleküler yanıt oranları: Türkiye’den tek merkez deneyimi

Fuat ERDEM, Yusuf BİLEN

The factors aff ecting noninvasive mechanical ventilation failure in COPD exacerbations

Meltem MİDİLLİ, Sedat ÜRKMEZ, Feza BACAKOĞLU, Mehmet Sezai TAŞBAKAN, Adnan Tolga ÖZ, Özen BAŞOĞLU KAÇMAZ, Alev GÜRGÜN, Pervin EKREN KORKMAZ

Skin prick test results and prevalence of allergic symptoms in workers exposed to toluene

Melike DEMİR, Tevfik PINAR, İsmail KARABULUT, Hayriye KARABULUT, Rıza Murat KARAŞEN, Gülistan KARADENİZ

A case with type IV dual left anterior descending coronary artery detected by multidetector computed tomography

Hüseyin AYHAN, Melike Ruşen METİN, Telat KELEŞ, Tahir DURMAZ, Engin BOZKURT

Th e perfect food for perfect health and pleasure?

Cem EKMEKÇİOĞLU

A comparative study of preoperative versus intraoperative meperidine administration in patients receiving general anesthesia: a prospective, randomized double-blind study

Bünyamin MUSLU, Hüseyin SERT, Önder SÜRGİT, Muhammet GÖZDEMİR, Rüveyda İrem DEMİRCİOĞLU, Ümmügülsüm YAZICI, Burhanettin USTA

Reducing hospital infection rates in the burn unit by adherence to infection control measures: a six-year experience

Kemalettin ÖZDEN, Ülkü ALTOPARLAK, Serpil EROL, Zülal ÖZKURT, Sibel YILMAZ İBA, Müfide Nuran AKÇAY