Narkolepsili hastalarda omega-3 yağ asit desteğinin plazma oreksin A, plazma yağ asitleri ve antropometrik ölçümlere etkisi

Amaç: Bu çalışmada narkolepsili hastalarda omega-3 (n-3) yağ asit desteğinin plazma oreksin A, plazma yağ asitleri ve antropometrik ölçümlere etkisini saptamak amaçlanmıştır.Yöntem ve gereç: Çalışma, 21-55 yaş arası 31 erkek birey (17 narkolepsili ve 14 sağlıklı) üzerinde yapılmıştır. Gruplara iki ay süresince günlük 1,4 g n-3 yağ asidi desteği verilmiştir. Çalışma başlangıcında ve sonunda bireylerin antropometrik ölçümleri alınmış plazmada oreksin, yağ asitleri ve diğer biyokimyasal parametreler analiz edilmiştir. Bulgular: Çalışma sonunda, hasta grubun antropometrik ölçüm ve diğer vücut bileşim değerlerinde istatistiksel olarak önemli değişiklik yokken (P > 0,05), kontrol grubunun vücut ağırlığı, beden kitle indeksi, bel/kalça oranı, vücut yağ (kg, %) değerlerindeki artış istatistiksel açıdan önemli bulunmuştur (P < 0,05). Hastaların çalışma başı ve sonunda plazma oreksin A düzeylerinde hem grup içi hem de gruplar arasında fark gözlenmemiştir (P > 0,05). Yine hastaların plazma seratonin düzeyleri çalışma başına göre, sonunda azalmış, insülin düzeyleri ise yükselmiştir (P < 0,05). Bireylerin grup içinde plazma n-6/n-3 oranında çalışma sonunda azalma olmasına karşın istatistiksel açıdan önemli değildir (P > 0,05). Plazma n-6/n-3 oranında gruplar arasında ise istatistiksel farklılık görülmüştür (P < 0,05). Kontrol grubundaki bireylerin çalışma başında plazma oreksin A düzeyi ile plazma n-3 yağ asitleri arasında korelasyon görülmüştür (P < 0,05). Yine çalışmada n-3 suplemantasyonu ardından yağ asitlerinin artmasına bağlı olarak plazma oreksin A düzeyi ile bazı yağ asitleri arasında korelasyon gözlenmiştir (P < 0,05). Sonuç: Bu veriler; n-3 yağ asidi desteğinin plazma oreksin A düzeyini yükseltmediğini ancak diğer bazı biyokimyasal parametreleri etkilediğini göstermektedir.

Anahtar Kelimeler:

Narkolepsi, uyku, oreksin, n-3 yağ asitleri, beden kütle indeksi, antropometrik ölçümler

The effect of omega-3 fatty acid supplementation on plasma orexin A, plasma fatty acids, and anthropometric measurements in patients with narcolepsy

To determine the effect of omega-3 (n-3) fatty acid supplementation on plasma orexin A, plasma fatty acids, and anthropometric measurements in patients with narcolepsy. Materials and methods: The study was performed on 17 males with narcolepsy and 14 healthy males between the ages of 21-55. An n-3 fatty acid supplement of 1.4 g/day was administered to the groups for 2 months. The anthropometric measurements of the individuals were taken at the onset and the end of trial, and orexin, fatty acids, and other biochemical parameters in the plasma were analyzed. Results: While there was no statistically significant change in anthropometric measurements or the other body composition values of the patient group (P > 0.05), there was a statistically significant increase in the body weight, body mass index, waist-to-hip ratio, and body fat mass values (kg, %) of the control group (P < 0.05). There was no difference in the levels of plasma orexin A of the patients within or between groups in the pre- and poststudy measurements (P > 0.05). The poststudy plasma serotonin levels of the patients were lower and plasma insulin levels were higher than in the initial study (P < 0.05). There was a correlation between the plasma orexin A levels and plasma n-3 fatty acids in individuals in the control group at the onset of the study (P < 0.05). Depending on the increase of the fatty acids after the n-3 supplementation, a correlation between plasma orexin A levels and some fatty acids was observed (P < 0.05). Conclusion: The data demonstrated that supplementation of n-3 fatty acid did not enhance the plasma orexin A level but did affect some other biochemical parameters.

Keywords:

Key words: Narcolepsy, sleep, orexin, n-3 fatty acid, body mass index, anthropometric measurements,

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