Postoperative cognitive dysfunction and Alzheimer disease

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β (Aβ) converge to indicate that anesthetics could affect AD pathogenesis, either directly or indirectly. Careful evaluation of the mental state should be mandatory for all elderly patients undergoing GA. Long-term prospective, randomized clinical studies are required to examine the relationship between POCD and AD.

Postoperative cognitive dysfunction and Alzheimer disease

Alzheimer disease (AD) is the most prevalent neurodegenerative disorder in elderly people. Patients with AD appear to be particularly at risk for cognitive deterioration following anesthesia. Some in vitro studies suggest that exposure to general anesthesia (GA) promotes the AD process. On the other hand, there are no clinical studies that clearly demonstrate that GA is a cause of cognitive dysfunction in patients with probable AD. The aim of this research was to discuss the relation between postoperative cognitive dysfunction (POCD) and AD according to the literature. In vivo studies examining AD biomarkers postoperatively and in vitro studies exploring amyloid-β (Aβ) converge to indicate that anesthetics could affect AD pathogenesis, either directly or indirectly. Careful evaluation of the mental state should be mandatory for all elderly patients undergoing GA. Long-term prospective, randomized clinical studies are required to examine the relationship between POCD and AD.

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Bibtex @ { tbtkmedical149038, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1015 - 1019}, doi = {}, title = {Postoperative cognitive dysfunction and Alzheimer disease}, key = {cite}, author = {Işık, BERRİN} }
APA Işık, B . (2015). Postoperative cognitive dysfunction and Alzheimer disease . Turkish Journal of Medical Sciences , 45 (5) , 1015-1019 .
MLA Işık, B . "Postoperative cognitive dysfunction and Alzheimer disease" . Turkish Journal of Medical Sciences 45 (2015 ): 1015-1019 <
Chicago Işık, B . "Postoperative cognitive dysfunction and Alzheimer disease". Turkish Journal of Medical Sciences 45 (2015 ): 1015-1019
RIS TY - JOUR T1 - Postoperative cognitive dysfunction and Alzheimer disease AU - BERRİN Işık Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1015 EP - 1019 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Postoperative cognitive dysfunction and Alzheimer disease %A BERRİN Işık %T Postoperative cognitive dysfunction and Alzheimer disease %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U
ISNAD Işık, BERRİN . "Postoperative cognitive dysfunction and Alzheimer disease". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1015-1019 .
AMA Işık B . Postoperative cognitive dysfunction and Alzheimer disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1015-1019.
Vancouver Işık B . Postoperative cognitive dysfunction and Alzheimer disease. Turkish Journal of Medical Sciences. 2015; 45(5): 1015-1019.
IEEE B. Işık , "Postoperative cognitive dysfunction and Alzheimer disease", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1015-1019, Ara. 2015
Turkish Journal of Medical Sciences
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

53.5b40.7b

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Postoperative cognitive dysfunction and Alzheimer disease

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