Gastrointestinal Stromal Tumor with Pulmonary Metastasis

Gastrointestinal stromal tumor (GIST) is rare but is the most common mesenchymal tumor of the gastrointestinal tract. It is usually arises from the stomach and small intestine. We present a case of GIST treated with surgery and adjuvant imatinib mesylate for pulmonary metastasis.

Gastrointestinal Stromal Tumor with Pulmonary Metastasis

Gastrointestinal stromal tumor (GIST) is rare but is the most common mesenchymal tumor of the gastrointestinal tract. It is usually arises from the stomach and small intestine. We present a case of GIST treated with surgery and adjuvant imatinib mesylate for pulmonary metastasis.

___

  • 1. Gold JS, De Matteo RP. Combined Surgical and Molecular Therapy, the Gastrointestinal Stromal Tumor Model. Ann Surg 2006; 244: 176-84.
  • 2. Segal NH, Pavlidis P, Antonescu CR, Maki RG, Noble WS, DeSantis D et al. Classification and subtype prediction of adult soft tissue sarcoma by functional genomics. American Journal of Pathology 2003; 163: 691-700.
  • 3. Allander SV, Nupponen NN, Ringner M, Hostetter G, Maher GV, Goldberger N et al. Gastrointestinal stromal tumors with KIT mutations exhibit a remarkably homogeneous gene expression profile. Cancer Res 2001; 61: 8624-8.
  • 4. Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, O'Connel JX et al. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet 2002; 359: 1301-7.
  • 5. Nishida T, Hirota S, Taniguchi M, Hashimoto K, Isozaki K, Nakamura H et al. Familial gastrointestinal stromal tumours with germline mutation of the KIT gene. Nat Genet 1998; 19: 323-4.
  • 6. Langer C, Gunawan B, Schuler P, Huber W, Fuzesi L, Becker H. Prognostic factors influencing surgical management and outcome of gastrointestinal stromal tumors. Br J Surg. 2003; 90: 332-9.
  • 7. Miettinen M, El-Rifai WE, HL Sobin L, Lasota J. Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: a review. Hum Pathol 2002; 33: 478-83.
  • 8. Ersoy E, Özdo¤an M, Demira¤ A, Aktimur R, Kulcoglu H, Gundogdu H. Giant adrenal myelolipoma associated with small bowel leiomyosarcoma. Turk J Gastroenterol 2006; 17: 126-9.
  • 9. Blay JY, Bonvalot S, Casali P, Choi H, Debiec-Richter M, Dei Tos AP et al. Consensus meeting for the management of gastrointestinal stromal tumors: Report of the GIST Consensus Conference of 20-21 March 2004, under the auspices of ESMO. Ann Oncol 2005; 16: 566-78.
  • 10. DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival. Ann Surg 2000; 231: 51-8.
Turkish Journal of Medical Sciences-Cover
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK