Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography

Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls. Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and education-matched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results: The average RNFL thickness was 84 ± 7.0 &mu;m in AD patients and 107 ± 6.3 &mu;m in healthy subjects (P < 0.001). The mean MMSE score was 21.9 ± 2.13 in AD patients. There was no significant correlation between the RNFL thickness and MMSE score. Conclusion: Patients with AD had reduced RNFL thickness in all quadrants compared with the control group. This finding suggests that RNFL thickness analysis may be useful in the early diagnosis of AD.

Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography

Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls. Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and education-matched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results: The average RNFL thickness was 84 ± 7.0 &mu;m in AD patients and 107 ± 6.3 &mu;m in healthy subjects (P < 0.001). The mean MMSE score was 21.9 ± 2.13 in AD patients. There was no significant correlation between the RNFL thickness and MMSE score. Conclusion: Patients with AD had reduced RNFL thickness in all quadrants compared with the control group. This finding suggests that RNFL thickness analysis may be useful in the early diagnosis of AD.

Kaynakça

Hirtz D, Thurman DJ, Gwinn-Hardy K, Mohamed M, Chaudhuri AR, Zalutsky R. How common are the “common” neurologic disorders? Neurology 2007; 68: 326–337.

Brookmeyer R, Johnson E, Ziegler-Graham K, Arrighi HM. Forecasting the global burden of Alzheimer’s disease. Alzheimers Dement 2007; 3: 186–191.

Frost S, Martins RN, Kanagasingam Y. Ocular biomarker for early detection of Alzheimer’s disease. J Alzheimers Dis 2010; 22: 1–16.

Valenti DA. Alzheimer’s disease: visual system review. Optometry 2010; 81: 12–21.

Koronyo-Hamaoui M, Koronyo Y, Ljubimov AV, Miller CA, Ko MK, Black KL, Schwartz M, Farkas DL. Identification of amyloid plaques in retinas from Alzheimer’s patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model. Neuroimage 2011; 54: 204–217.

Oliveira LT, Louzada PR, Mello FG, Ferreira ST. Amyloid-β decreases nitric oxide production in cultured retinal neurons: a possible mechanism for synaptic dysfunction in Alzheimer’s disease? Neurochem Res 2011; 36: 163–169.

Guo L, Duggan J, Corderio MF. Alzheimer’s disease and retinal neurodegeneration. Curr Alzheimer Res 2010; 7: 3–14.

Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA et al. Optical coherence tomography. Science 1991; 254: 1178– 1181.

Parisi V, Restuccia R, Fattapposta F, Mina C, Bucci MG, Pierelli F. Morphological and functional retinal impairment in Alzheimer’s disease patients. Clin Neurophysiol 2001; 112: 1860–1867.

Berisha F, Feke GT, Trempe CL, McMeel JW, Schepens CL. Retinal abnormalities in early Alzheimer’s disease. Invest Ophthalmol Vis Sci 2007; 48: 2285–2289.

Chi Y, Wang YH, Yang L. The investigation of retinal nerve fiber loss in Alzheimer’s disease. Zhonghua Yanke Zazhi 2010; 46: 134–139 (in Chinese with English abstract).

Kesler A, Vakhapova V, Korczyn AD, Naftaliev E, Neudorfer M. Retinal thickness in patients with mild cognitive impairment and Alzheimer’s disease. Clin Neurol Neurosurg 2011; 113: 523–526.

He XF, Liu YT, Peng C, Zhang F, Zhuang S, Zhang JS. Optical coherence tomography assessed retinal nerve fiber layer thickness in patients with Alzheimer’s disease: a meta-analysis. Int J Ophthalmol 2012; 5: 401–405.

Larrosa JM, Garcia-Martin E, Bambo MP, Pinilla J, Polo V, Otin S, Satue M, Herrero R, Pablo LE. Potential new diagnostic tool for Alzheimer’s disease using a linear discriminant function for Fourier domain optical coherence tomography. Invest Ophthalmol Vis Sci 2014; 55: 3043–3051.

Shen Y, Liu L, Cheng Y, Feng W, Shi Z, Zhu Y, Wu W, Li C. Retinal nerve fiber layer thickness is associated with episodic memory deficit in mild cognitive impairment patients. Curr Alzheimer Res 2014; 11: 259–266.

McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 1984; 34: 939–944.

Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A, Winblad B. Very old women at highest risk of dementia and Alzheimer’s disease: incidence data from the Kungsholmen Project, Stockholm. Neurology 1997; 48: 132–138.

Korezyn AD, Aharonson V. Computerized methods in the assessment and prediction of dementia. Curr Alzheimer Res 2007; 4: 364–369.

Portet F, Scarmeas N, Cosentino S, Helzner EP, Stern Y. Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study. Arch Neurol 2009; 66: 1120–1126.

Kaynak Göster

Bibtex @ { tbtkmedical149050, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2015}, volume = {45}, pages = {1094 - 1097}, doi = {}, title = {Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography}, key = {cite}, author = {Güneş, Alime and Demirci, Seden and Tök, Levent and Tök, Özlem and Demirci, Serpil} }
APA Güneş, A , Demirci, S , Tök, L , Tök, Ö , Demirci, S . (2015). Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography . Turkish Journal of Medical Sciences , 45 (5) , 1094-1097 . Retrieved from https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149050
MLA Güneş, A , Demirci, S , Tök, L , Tök, Ö , Demirci, S . "Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography" . Turkish Journal of Medical Sciences 45 (2015 ): 1094-1097 <https://dergipark.org.tr/tr/pub/tbtkmedical/issue/12392/149050>
Chicago Güneş, A , Demirci, S , Tök, L , Tök, Ö , Demirci, S . "Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography". Turkish Journal of Medical Sciences 45 (2015 ): 1094-1097
RIS TY - JOUR T1 - Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography AU - Alime Güneş , Seden Demirci , Levent Tök , Özlem Tök , Serpil Demirci Y1 - 2015 PY - 2015 N1 - DO - T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 1094 EP - 1097 VL - 45 IS - 5 SN - 1300-0144-1303-6165 M3 - UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography %A Alime Güneş , Seden Demirci , Levent Tök , Özlem Tök , Serpil Demirci %T Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography %D 2015 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 45 %N 5 %R %U
ISNAD Güneş, Alime , Demirci, Seden , Tök, Levent , Tök, Özlem , Demirci, Serpil . "Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography". Turkish Journal of Medical Sciences 45 / 5 (Aralık 2015): 1094-1097 .
AMA Güneş A , Demirci S , Tök L , Tök Ö , Demirci S . Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography. Turkish Journal of Medical Sciences. 2015; 45(5): 1094-1097.
Vancouver Güneş A , Demirci S , Tök L , Tök Ö , Demirci S . Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography. Turkish Journal of Medical Sciences. 2015; 45(5): 1094-1097.
IEEE A. Güneş , S. Demirci , L. Tök , Ö. Tök ve S. Demirci , "Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography", Turkish Journal of Medical Sciences, c. 45, sayı. 5, ss. 1094-1097, Ara. 2015

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