The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

To investigate if there is any association between the serum folate and vitamin B12 status and the depressive symptoms in postmenopausal women. Materials and methods: The study included 95 postmenopausal women. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess their depressive symptoms. The investigated women were classified into 2 groups based on the existence of depressive symptoms. These 2 groups were compared in terms of folic acid and vitamin B12 levels. Results: Among 95 cases, 27 postmenopausal women scored 16 or more on the CES-D scale and were classified as the depressive group (Group 1), and 68 postmenopausal women scored 15 or less and were classified as the nondepressive group (Group 2). The serum levels of folate were 11.5 ± 5.4 ng/mL in group 1 and 12.3 ± 5.3 ng/mL in group 2. The concentrations of vitamin B12 were 456.2 ± 343.4 pg/mL in group 1 and 446.5 ± 165.1 pg/mL in group 2. The folate and vitamin B12 levels did not significantly correlate to the frequency of depressive symptoms (P = 0.52 and P = 0.24, respectively). Conclusion: In this study, no correlation was detected between serum folate and vitamin B12 levels and depressive symptoms in postmenopausal women. Supplementation of folic acid and vitamin B12 for postmenopausal women does not seem to be an effective intervention to reduce depressive symptoms.

The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women

To investigate if there is any association between the serum folate and vitamin B12 status and the depressive symptoms in postmenopausal women. Materials and methods: The study included 95 postmenopausal women. The Center for Epidemiologic Studies Depression Scale (CES-D) was used to assess their depressive symptoms. The investigated women were classified into 2 groups based on the existence of depressive symptoms. These 2 groups were compared in terms of folic acid and vitamin B12 levels. Results: Among 95 cases, 27 postmenopausal women scored 16 or more on the CES-D scale and were classified as the depressive group (Group 1), and 68 postmenopausal women scored 15 or less and were classified as the nondepressive group (Group 2). The serum levels of folate were 11.5 ± 5.4 ng/mL in group 1 and 12.3 ± 5.3 ng/mL in group 2. The concentrations of vitamin B12 were 456.2 ± 343.4 pg/mL in group 1 and 446.5 ± 165.1 pg/mL in group 2. The folate and vitamin B12 levels did not significantly correlate to the frequency of depressive symptoms (P = 0.52 and P = 0.24, respectively). Conclusion: In this study, no correlation was detected between serum folate and vitamin B12 levels and depressive symptoms in postmenopausal women. Supplementation of folic acid and vitamin B12 for postmenopausal women does not seem to be an effective intervention to reduce depressive symptoms.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical146671, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2014}, volume = {44}, pages = {611 - 615}, doi = {10.3906/kim-1302-78}, title = {The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women}, key = {cite}, author = {Şengül, Özlem and Uygur, Dilek and Güleç, Mustafa and Dilbaz, Berna and Şimşek, Esma Meltem and Göktolga, Ümit} }
APA Şengül, Ö , Uygur, D , Güleç, M , Dilbaz, B , Şimşek, E , Göktolga, Ü . (2014). The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women . Turkish Journal of Medical Sciences , 44 (4) , 611-615 . DOI: 10.3906/kim-1302-78
MLA Şengül, Ö , Uygur, D , Güleç, M , Dilbaz, B , Şimşek, E , Göktolga, Ü . "The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women" . Turkish Journal of Medical Sciences 44 (2014 ): 611-615 <
Chicago Şengül, Ö , Uygur, D , Güleç, M , Dilbaz, B , Şimşek, E , Göktolga, Ü . "The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women". Turkish Journal of Medical Sciences 44 (2014 ): 611-615
RIS TY - JOUR T1 - The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women AU - Özlem Şengül , Dilek Uygur , Mustafa Güleç , Berna Dilbaz , Esma Meltem Şimşek , Ümit Göktolga Y1 - 2014 PY - 2014 N1 - doi: 10.3906/kim-1302-78 DO - 10.3906/kim-1302-78 T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 611 EP - 615 VL - 44 IS - 4 SN - 1300-0144-1303-6165 M3 - doi: 10.3906/kim-1302-78 UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women %A Özlem Şengül , Dilek Uygur , Mustafa Güleç , Berna Dilbaz , Esma Meltem Şimşek , Ümit Göktolga %T The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women %D 2014 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 44 %N 4 %R doi: 10.3906/kim-1302-78 %U 10.3906/kim-1302-78
ISNAD Şengül, Özlem , Uygur, Dilek , Güleç, Mustafa , Dilbaz, Berna , Şimşek, Esma Meltem , Göktolga, Ümit . "The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women". Turkish Journal of Medical Sciences 44 / 4 (Mayıs 2014): 611-615 .
AMA Şengül Ö , Uygur D , Güleç M , Dilbaz B , Şimşek E , Göktolga Ü . The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women. Turkish Journal of Medical Sciences. 2014; 44(4): 611-615.
Vancouver Şengül Ö , Uygur D , Güleç M , Dilbaz B , Şimşek E , Göktolga Ü . The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women. Turkish Journal of Medical Sciences. 2014; 44(4): 611-615.
IEEE Ö. Şengül , D. Uygur , M. Güleç , B. Dilbaz , E. Şimşek ve Ü. Göktolga , "The comparison of folate and vitamin B12 levels between depressive and nondepressive postmenopausal women", Turkish Journal of Medical Sciences, c. 44, sayı. 4, ss. 611-615, May. 2014, doi:10.3906/kim-1302-78
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

23.9b 22.4b

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