Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran

Several types of the hepatitis C virus (HCV), with variations in different parts of the genome, have been isolated from different regions of the world. Based on heterogenic sequences in the isolated genome, HCV is classified into different genotypes and subtypes. Data on distribution of HCV genotypes in a certain region could be important to patient management. Therefore, this study was conducted to determine the distribution of HCV in Mashhad, Northeast Iran. Materials and methods: This cross-sectional study was conducted on 103 patients with HCV infections in Mashhad. Among the participants, at least 22 (21.4%) were intravenous drug users. HCV seropositivity was determined by an enzyme-linked immunosorbent assay and was confirmed by reverse transcriptase polymerase chain reaction. HCV-positive samples were selected for HCV genotyping using genotype specific primers. Results: Of 103 subjects, 43 (41.7%) and 34 (33.0%) had genotypes 1a and 3a, respectively. Other genotypes including 1b, 2a, 2b, 3b, and 5a were found in 4 (3.9%), 1 (1.0%), 3 (2.9%), 4 (3.9%), and 1 (1.0%), respectively. Coinfections with 2 genotypes were also observed in 11 (10.7%) patients. Genotyping for 2 (1.9%) of 103 samples did not produce any results. Conclusion: Genotypes 1a and 3a were found to be the most prevalent HCV genotypes in Mashhad, Iran.

Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran

Several types of the hepatitis C virus (HCV), with variations in different parts of the genome, have been isolated from different regions of the world. Based on heterogenic sequences in the isolated genome, HCV is classified into different genotypes and subtypes. Data on distribution of HCV genotypes in a certain region could be important to patient management. Therefore, this study was conducted to determine the distribution of HCV in Mashhad, Northeast Iran. Materials and methods: This cross-sectional study was conducted on 103 patients with HCV infections in Mashhad. Among the participants, at least 22 (21.4%) were intravenous drug users. HCV seropositivity was determined by an enzyme-linked immunosorbent assay and was confirmed by reverse transcriptase polymerase chain reaction. HCV-positive samples were selected for HCV genotyping using genotype specific primers. Results: Of 103 subjects, 43 (41.7%) and 34 (33.0%) had genotypes 1a and 3a, respectively. Other genotypes including 1b, 2a, 2b, 3b, and 5a were found in 4 (3.9%), 1 (1.0%), 3 (2.9%), 4 (3.9%), and 1 (1.0%), respectively. Coinfections with 2 genotypes were also observed in 11 (10.7%) patients. Genotyping for 2 (1.9%) of 103 samples did not produce any results. Conclusion: Genotypes 1a and 3a were found to be the most prevalent HCV genotypes in Mashhad, Iran.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical146678, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2014}, volume = {44}, pages = {656 - 660}, doi = {10.3906/sag-1305-64}, title = {Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran}, key = {cite}, author = {Afsharı, Reza and Nomanı, Hosein and Zanıanı, Fatemeh Riyahi and Nabavınıa, Maryam Sadat} }
APA Afsharı, R , Nomanı, H , Zanıanı, F , Nabavınıa, M . (2014). Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran . Turkish Journal of Medical Sciences , 44 (4) , 656-660 . DOI: 10.3906/sag-1305-64
MLA Afsharı, R , Nomanı, H , Zanıanı, F , Nabavınıa, M . "Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran" . Turkish Journal of Medical Sciences 44 (2014 ): 656-660 <
Chicago Afsharı, R , Nomanı, H , Zanıanı, F , Nabavınıa, M . "Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran". Turkish Journal of Medical Sciences 44 (2014 ): 656-660
RIS TY - JOUR T1 - Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran AU - Reza Afsharı , Hosein Nomanı , Fatemeh Riyahi Zanıanı , Maryam Sadat Nabavınıa Y1 - 2014 PY - 2014 N1 - doi: 10.3906/sag-1305-64 DO - 10.3906/sag-1305-64 T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 656 EP - 660 VL - 44 IS - 4 SN - 1300-0144-1303-6165 M3 - doi: 10.3906/sag-1305-64 UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran %A Reza Afsharı , Hosein Nomanı , Fatemeh Riyahi Zanıanı , Maryam Sadat Nabavınıa %T Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran %D 2014 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 44 %N 4 %R doi: 10.3906/sag-1305-64 %U 10.3906/sag-1305-64
ISNAD Afsharı, Reza , Nomanı, Hosein , Zanıanı, Fatemeh Riyahi , Nabavınıa, Maryam Sadat . "Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran". Turkish Journal of Medical Sciences 44 / 4 (Mayıs 2014): 656-660 .
AMA Afsharı R , Nomanı H , Zanıanı F , Nabavınıa M . Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran. Turkish Journal of Medical Sciences. 2014; 44(4): 656-660.
Vancouver Afsharı R , Nomanı H , Zanıanı F , Nabavınıa M . Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran. Turkish Journal of Medical Sciences. 2014; 44(4): 656-660.
IEEE R. Afsharı , H. Nomanı , F. Zanıanı ve M. Nabavınıa , "Genotype distribution of hepatitis C virus in Khorasan Razavi Province, Iran", Turkish Journal of Medical Sciences, c. 44, sayı. 4, ss. 656-660, May. 2014, doi:10.3906/sag-1305-64
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

24.6b 23.7b

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