On the Qualitative Analysis of the Uniqueness of the Movement of Endothelial Cells

This paper extends the work of Pamuk (2003) by showing mathematically that the movement of endothelial cells, to the regions where active enzyme is large or where fibronectin is small, is unique. To do this, we obtain the existence and uniqueness of the steady-state solution of an initial-boundary value problem which mathematically models endothelial cell movement in tumor angiogenesis. A specific example showing the instability of this steady-state solution is provided.

On the Qualitative Analysis of the Uniqueness of the Movement of Endothelial Cells

This paper extends the work of Pamuk (2003) by showing mathematically that the movement of endothelial cells, to the regions where active enzyme is large or where fibronectin is small, is unique. To do this, we obtain the existence and uniqueness of the steady-state solution of an initial-boundary value problem which mathematically models endothelial cell movement in tumor angiogenesis. A specific example showing the instability of this steady-state solution is provided.

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  • Bellomo, N., Li, N.K., Maini, P.K., On the foundations of cancer modelling: Selected topics, speculations, and perspectives, Math. Mod. Math. Appl. S. 18(4), 593-646 (2008).
  • Davis, B., Reinforced random walks, Probal. Theory Related Fields 84, 203-229 (1990).
  • Farlow, S., Partial Differential Equations for Scientists and Engineering, Dover, 1993.
  • Folkman, J., Tumor angiogenesis: therapeutic implications, New Engl. J. Med 285, 1182-1186 (1971).
  • Folkman, J., The vascularization of tumors, Sci. Am., 234, 59-73 (1976).
  • Gunzburger, M. D., Peterson, J. S., Finite Element Methods, Iowa State Univ., Iowa, 1998.
  • Levine, H. A., Pamuk, S., Sleeman, B. D. , Nilsen-Hamilton, M., Mathematical modeling of capillary formation and development in tumor angiogenesis: Penetration into the stroma, Bull. Math. Biol. 63(5), 801–863 (2001).
  • Nicosia, R. F., Bonanno, E., Smith, M., Fibronectin promotes the elongation of microvessels during angiogenesis in vitro, Journal of cellular physiology. 154, 654-661 (1993).
  • Othmer, H. G., Stevens, A., Aggregation, blowup, and collapse: The ABC’s of taxis in reinforced random walks, SIAM J. Appl. Math. 57(4), 1044-1081 (1997).
  • Pamuk, S., Erdem, A., The method of lines for the numerical solution of a mathematical model for capillary formation: The role of endothelial cells in the capillary, Appl. Math. Comput. 186, 831-835 (2007).
  • Pamuk, S., Qualitative Analysis of a Mathematical Model for Capillary Formation in Tumor Angiogenesis, Math. Mod. Meth. Appl. Sci. 13(1), 19 33 (2003).
  • Pamuk, S., Steady State Analysis of a Mathematical Model for Capillary Network Formation in the Absence of Tumor Source, Math. Biosci. 189(1), 2138 (2004).
  • Paweletz, N., Knierim, M., Tumor-related angiogenesis, Crit. Rev. Oncology/Hematology. 9, 197-243 (1989).
  • Yamada, K. M., Olden, K., Fibronectins - adhesive glycoproteins of cell surface and blood, Nature. 275, 179-184 (1978). Erdem ALTUNTAC¸
  • Department of Mathematics, University of Kocaeli Umuttepe Campus, 41800, Kocaeli-TURKEY e-mail: erdemath@gmail.com Serdal PAMUK
  • Department of Mathematics, University of Kocaeli Umuttepe Campus, 41800, Kocaeli-TURKEY e-mail: spamuk@kocaeli.edu.tr