Kronik obstrüktif akciğer hastalığının akut alevlenmesi ile nötrofil-lenfosit oranı ve serum ürik asit düzeyleri arasındaki ilişki

Amaç: Kronik inflamasyon, kronik obstrüktif akciğer hastalığında (KOAH) patojenik bir rol oynamaktadır. Dolaşımdaki nötrofil-lenfosit oranı (N / L oranı), serum ürik asit ve gama-glutamil transferaz (GGT) düzeylerindeki artış, sistemik bir iltihabın göstergesi olabilir. Bu çalışmanın amaı KOAH'lı hastalarda biyolojik belirteç olarak kan nötrofil-lenfosit (N / L) oranı ile serum ürik asit ve gama-glutamil transferaz (GGT) düzeylerinin muhtemel rolü üzerindeki olası değerini değerlendirmektir. Gereç ve Yöntemler: Retrospektif bir çalışma.Gereç ve Yöntem: Örneklem, KOAH'ın stabil ve akut alevlenmesi için göğüs hastalıkları bölümümüze başvuran 260 hastadan (stabil KOAH, n = 68, KOAH'ın akut alevlenişi, n = 192) oluşturuldu. Bulgular: KOAH hastalarının akut alevlenmesinde yüksek N / L oranları ve serum ürik asit seviyeleri tespit edildi (p <0.01). Sigara (paket-yıllar) ile N / L oranı ve C-reaktif protein düzeyleri arasında pozitif korelasyon bulundu (sırasıyla p = 0.014; r = 0.153 ve p = 0.001; r = 0.252). Sonuçlar: Çalışmamız, akut KOAH alevlenmesi olan hastalarda N / L oranı ve serum ürik asit düzeylerinin belirgin olarak daha yüksek olduğunu göstermiştir. Kronik obstrüktif akciğer hastalığı ile bu parametreler arasındaki ilişkilerle ilgili olarak, rutin klinik uygulamada diğer risk faktörlerinin yanında hastalık yükünü belirlemek için kullanılabilirler.

Anahtar Kelimeler:

kronik obstriktif akciğer hastalığı, nötrofil lenfosit oranı inflamasyon, C reaktif protein, serum ürik asit, inflamasyon

The relationship between acute exacerbation of chronic obstructive pulmonary disease and neutrophile-to-lymphocyte ratio, serum uric acid and gamma-glutamyl transferase levels

Aim: Chronic inflammation plays a pathogenic role in chronic obstructive pulmonary disease. Increase in the ratio of circulating neutrophil to lymphocyte ratio (NLR), serum uric acid and gamma-glutamyl transferase (GGT) levels may serve as a marker of systemic inflammation. The aim of this study is to evaluate the potential predictive value of blood neutrophil-to- lymphocyte NLR and possible role of serum uric acid and gamma-glutamyl transferase levels as biomarkers in chronic obstructive pulmonary disease patients.Material and Methods: The sample was derived from a population of 276 patients admitted for acute exacerbation of chronic obstructive pulmonary disease to our respiratory medicine department.Results: Higher N/L ratios, uric acid and GGT levels were detected in chronic obstructive pulmonary disease patients than in the controls (P < 0.001). Positive correlations between smoking (pack-years) and NLR, serum GGT, uric acid, and C- reactive protein levels were found (P < 0.001; r = 0.339, P < 0.001; r = 0.224, P < 0.001;r = 0.242,and P < 0.001; r = 0.563, respectively). Conclusion: Our study demonstrated that NLR, serum GGT and uric acid levels are significantly higher in patients with chronic obstructive pulmonary disease. With regard to the associations between chronic obstructive pulmonary disease and these parameters, they can be used to determine disease burden besides other risk factors in routine clinical practice.

Keywords:

inflammation, C- reactive protein, Chronic obstructive pulmonary disease, neutrophil/lymphocyte ratio, serum uric acid,

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