Mehmet ZENGİN, Feray GÜNVER, Nevra DURSUN

Hobnail/mikropapiller varyant papiller tiroid karsinomu: varyant mı, patern mi

Papiller tiroid karsinomu, tiroid maligniteleri arasında en sık görülen tiptir ve tüm malignitelerin %1’ini oluşturur. Klasik papiller tiroid karsinomu oldukça iyi prognoza sahip olmakla beraber hastaların %10’unda rekürrens, lenf nodu metastazı, uzak organ metastazı ya da mortalite gelişebilmektedir. Bu agresiv klinik davranış çoğunlukla difüz sklerozan, uzun hücreli ve kolumnar hücreli gibi varyantlarda görülmektedir. Hobnail/mikropapiller varyant papiller tiroid karsinomu, papiller tiroid karsinomunun oldukça nadir görülen, yeni tarif edilen bir varyantıdır. Literatürde benzer şekilde çok az sayıda yayın mevcut olup, genellikle agresiv seyrettiği ve metastaz yapma potansiyelinin klasik papiller tiroid karsinomundan fazla olduğu bildirilmiştir. Ancak sitolojik özellikleri ve moleküler alt yapısı tam olarak anlaşılamamıştır. Bu yazıda; hobnail/mikropapiller varyant papiller tiroid karsinomlu bir hasta sunulmuş olup, tanı problemleri ve malignite kriterleri literatür bilgileri gözden geçirilerek tartışılmıştır.

Anahtar Kelimeler:

Papiller tiroid karsinomu, hobnail, mikropapiller

Hobnail/micropapillary variant papillary thyroid carcinoma: is it a variant or a pattern

Papillary thyroid carcinoma is the most common type of thyroid malignancies and constitutes 1% of all malignancies. Classical papillary thyroid carcinoma is very good prognosis; but recurrence, lymph node metastasis, distant organ metastasis or mortality can develop in 10% of patients. This aggressive clinical behavior is more often seen in variants such as diffuse sclerosis, tall cell and columnar cell. Hobnail/micropapillary variant papillary thyroid carcinoma is a relatively rare, newly described variant of papillary thyroid carcinoma. There are very few publications in the literature and it is reported that the aggressive course and metastasizing potential is greater than the classic papillary thyroid carcinoma. However, their cytological properties and molecular backround are not fully understood. In this article; a patient with hobnail/micropapillary variant papillary thyroid carcinoma has been presented, and diagnostic problems and malignancy criteria have been discussed by reviewing the literature.

Keywords:

Papillary thyroid carcinoma, hobnail, micropapillary,

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