Osman AYDIN, Şule KÖKTEN, İlhami ÇELİK, Hakan ÜNVER

N -Acylazole mediated stereoselective and regioselective synthesis of N -substituted azole acrylonitriles

Regio- and stereoselective synthesis of N -substituted azole acrylonitriles has been achieved smoothly inN, N -dimethylformamide (DMF) in the presence of potassium carbonate (K2 CO3) as a base catalyst. N -Substituted azole acrylonitriles were obtained in moderate to good yields (39%–87%) with a one-pot reaction between readily available N -acetylazoles and Baylis-Hillman nitriles. The structural determinations were accomplished by NOESY 1 H NMR and X-ray crystallography.

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