Gamze TAN, Gülçin BOLAT, Mehmet Ali ONUR, Serdar ABACI

7997

Determination of lidocaine based on electrocatalysis of a chemically modified electrode

The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.
Anahtar Kelimeler:

Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry

Determination of lidocaine based on electrocatalysis of a chemically modified electrode

The potential application of biochemically modified electrodes was investigated for construction of a drug biosensor. The electrocatalytic response of lidocaine was examined through modified electrodes using the electron transfer ability of hemoglobin (Hb) immobilized on gold film modified with a self-assembled monolayer (SAM) of 3-mercaptopropionic acid (MPA). According to the results of voltammetric studies, Au/MPA/Hb electrodes exhibited high sensitivity and good electrocatalytic activity for the reduction of lidocaine, motivating us to construct drug biosensors. With this study, a new electroanalytical procedure is proposed for the determination of lidocaine level in medical applications or therapeutic formulations containing lidocaine as the active ingredient.
Keywords:

Lidocaine, hemoglobin, chemically modified electrodes, drug biosensor, electrochemistry,

PDF
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Simultaneous determination of dopamine, uric acid, and tryptophan using an MWCNT modified carbon paste electrode by square wave voltammetry

Hadi BEITOLLAHI, Alireza MOHADESI, Saeedeh KHALILIZADEH MAHANI

Three-component Passerini-Smiles coupling reaction of aldehydes and isocyanides with tropolone catalyzed by silica nanoparticles

Abdolhossain MASSOUDI, Issa AMINI, Ali RAMAZANI And

Determination of lidocaine based on electrocatalysis of a chemically modified electrode

Gamze TAN, Gülçin BOLAT, Mehmet Ali ONUR, Serdar ABACI

Synthesis and structural characterization of novel square pyramidal oxovanadium(IV) complexes with ligands having N and O donor atoms

Ashok Kumar YADAVA, Hardeo Singh YADAV, Uma Shanker YADAV

Facile and rapid synthesis of some novel polysubstituted imidazoles by employing magnetic Fe3O4 nanoparticles as a high efficient catalyst

Bahador KARAMI, Khalil ESKANDARI, Abdolmohammad GHASEMI

Symmetric, twinned, and double-decker phthalocyanines substituted by trialkylated pentaerythritol

Muzaffer KÖÇ, Ayşe Gül GÜREK, Fabienne DUMOULİN, Vefa AHSEN

A new absorption based CO2 sensor based on Schiff base doped ethyl cellulose

Sevinç Zehra TOPAL, Kadriye ERTEKİIN, Berrin YENİIGÜL, Ayşe ERÇAĞ

Microwave-assisted synthesis, spectroscopy, and crystal structures of $[(H_2 -(4,4'-bipy)]^{2+} [Cr_2O_7]^{2−}$ and one-dimensional polymeric ${[Mn(4,4' -bipy)(Cr_2O_7)(H_2O)_2]}_n$ compounds

Hirihattaya PHETMUNG, Munee WATEH, Chaveng PAKAWATCHAI

Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents

Meriç KÖKSAL AKKOÇ, Mine YARIM YÜKSEL, İrem DURMAZ

In situ formed 1-hexyl-3-methylimidazolium hexafluorophosphate for dispersive liquid-liquid microextraction of Pd(II) prior to electrothermal AAS and spectrophotometry

Habibollah ESKANDARI