An efficient synthesis of some new bisbenzimidazoles via microwave technique
2,2'-[1,4 (1,3)-Phenylenedi(methylene)]bis-1H-benzimidazole derivatives were obtained from the reaction of 1,4- or (1,3)-bisiminoester hydrochloride and o-phenylenediamine derivatives under microwave irradiation. Ester and hydrazide derivatives were prepared from a free NH group. This practical method revealed good results for yield, reaction time, and quick isolation of products.
An efficient synthesis of some new bisbenzimidazoles via microwave technique
2,2'-[1,4 (1,3)-Phenylenedi(methylene)]bis-1H-benzimidazole derivatives were obtained from the reaction of 1,4- or (1,3)-bisiminoester hydrochloride and o-phenylenediamine derivatives under microwave irradiation. Ester and hydrazide derivatives were prepared from a free NH group. This practical method revealed good results for yield, reaction time, and quick isolation of products.
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- Stevenson, C.; Davies, R.; Jeremy, H. Chem. Res. Toxicol. 1999, 12, 38–45.
- Grimmett, M. R. Science of Synthesis 2002, 12, 529–612.
- Sierra-Zenteno, A.; Gal´ an-Vidal, C.; Tapia-Benavides, R. J. Mex. Chem. Soc. 2002, 46, 125–130.
- K¨ u¸ c¨ ukbay, H.; Yılmaz, ¨ U.; S ¸ireci, N.; ¨ Onganer, A. N. Turk. J. Chem. 2011, 35, 561–571.
- Ku¸s, C.; Altanlar, N. Turk. J. Chem. 2003, 27, 35–39.
- Utku, S.; Topal, M.; D¨ o˘ gen, A.; Serin, M. S. Turk. J. Chem. 2010, 34, 427–436.
- G¨ uven, ¨ O. ¨ O.; Erdo˘ gan, T.; G¨ oker, H.; Yıldız, S. Bioorg. Med. Chem. Lett. 2007, 17, 2233–2236.
- Hao, J. Y.; Ge, Z. Y.; Yang, S. Y. Synth. Commun. 2003, 33, 79–86.
- Zhang, Z. H.; Li, J. J.; Gao, Y. Z.; Liu, Y. H. J. Heterocyclic Chem. 2007, 44, 1509–1512.
- Wang, Z. X.; Qin, H. L. J. Heterocyclic Chem. 2005, 42, 1001–1005.
- Yoel, T.; Levine, H. H.; Levy, M. J. Polymer Sci. Polym. Chem. Ed. 1974, 12, 1515–1529.
- Pinner, A. Die Imido¨ ather und ihre Derivate; Oppenheim: Berlin, Germany, 1892.
- Kahveci, B.; Yılmaz, F.; Mente¸se, E.; Beri¸s, F. S ¸. J. Chem. Res. 2012, 8, 484–488.
- Ansari, K. F.; Lal, C. Eur. J. Med. Chem. 2009, 44, 4028–4033.
- Kahveci, B.; Yılmaz, F.; Mente¸se, E.; ¨ Ozil, M.; Karao˘ glu, S ¸. A., J. Heterocyclic Chem. in press. DOI 10.1002/jhet.1593. Desai, K. G.; Desai, K. R. Bioorg. Med. Chem. 2006, 14, 8271–8279.