Mahesh CHAND, Reena KAUSHIK, Subhash Chand JAIN

193103

Synthesis and antimicrobial and antioxidant activities of hybrid molecules containing benzotriazole and 1,2,4-triazole

Eleven novel 1,2,4-triazolylbenzotriazoles have been prepared using 1-(hydrazinylcarbonylmethyl)-1$H$-benzot- riazole (3) as a potent intermediate. Compound 3, however, was obtained from benzotriazole in two steps. All synthesized compounds were characterized by detailed spectral studies like IR, $^{1}$H NMR, $^{13}$C NMR, and mass spectrometry. All synthesized compounds were evaluated for their \textit{in vitro} antimicrobial activity against seven strains of bacteria and four strains of fungi. Compounds 13, 17, 19, 20, and 21}were found to possess antibacterial activity comparable to that of ciprofloxacin against a Klebsiella pneumoniae strain. Except for compounds2 and 13, all compounds showed good antifungal activity against an Aspergillus niger strain as compared to miconazole. The synthesized compounds were also evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and the results are encouraging, especially for compounds 3,20, and 21.
Keywords:

Benzotriazole, 1, 2 4-triazole, triazolylbenzotriazole, antimicrobial and antioxidant activities,

PDF
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Metal nanoparticles/carbon nanotube modified electrodes for voltammetric determination of boron

Nuri NAKİBOĞLU, Zekerya DURSUN, Lokman LİV

Mustafa BENER, Mustafa Reşat APAK

Novel optical sensor-based method for determining total tocopherol content in serum

Mustafa BENER, Reşat APAK

Ahsan IQBAL, Zulfiqar Ali KHAN, Sohail Anjum SHAHZAD, Muhammad USMAN, Shakeel Ahmad KHAN, Abdul H. FAUQ, Ayesha BARI, Muhammad Aamir SAJID

Synthesis, spectroscopic characterization, and computational studies of 2-cyano-6-hydroxybenzothiazole: a key synthetic intermediate of firefly luciferin

Ghasem SHAHMORADI, Saeid AMANI

Nataliia STRUTYNSKA, Nikolai SLOBODYANIK, Anastasiia SHATALOVA

An efficient water-mediated synthetic route for the alkylation of heteroarenes

Pınar SEYİTDANLIOĞLU, Essam Hamied Ahmed HANASHALSHAHABY, Canan ÜNALEROĞLU

Determination of hydrogen peroxide with an enzymeless amperometric sensor based on poly(vinylferrocene)-supported Ag nanoparticles

Mutlu SÖNMEZ ÇELEBİ, Kübra ÖZTÜRK, Mehmet DUMANGÖZ, Filiz KURALAY

Recent synthetic methodologies for pyrimidine and its derivatives

Matloob AHMAD, Farhat IBRAHEEM, Furqan Ahmad SADDIQUE, Asim MANSHA, Sana ASLAM, Tahir FAROOQ

Synthesis and investigation of langbeinite-related strontium- and iron-containing phosphates

Nataliia STRUTYNSKA, Nikolai SLOBODYANIK, Anastasiia SHATALOVA