Pınar SEYİTDANLIOĞLU, Essam Hamied Ahmed HANASHALSHAHABY, Canan ÜNALEROĞLU

An efficient water-mediated synthetic route for the alkylation of heteroarenes

An efficient synthetic route has been described for the alkylation of 1H -indole, 1H -benzimidazole, and1H -benzotriazole. This approach features the alkylation of heteroaromatics through in situ generated enones fromketonic Mannich bases under metal-free conditions. A series of alkylated heteroaromatics have been synthesized via theK10 catalyzed alkylation reactions of these heteroaromatics with a variety of ketonic Mannich bases. Environmentallybenign K10 catalyst, water-mediated mild reaction conditions, and the efficient synthesis of alkylated products are theadvantages of this alkylation method.

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