Md. Masudur RAHMAN, Md. Aslam HOSSAIN, Saiful Alam SIDDIQUE

Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract

Alocasia macrorrhizos (L.) (Araceae), a coarse and erect plant that is widely cultivated to be eaten as a vegetable throughout Bangladesh, has been reported to possess a number of medicinal properties. The antihyperglycemic, antioxidant, and cytotoxic effects of the methanol extract of A. macrorrhizos rhizomes were investigated. The extract was given at a single dose (250 and 500 mg/kg) in alloxan-induced hyperglycemic mice. The extract at 500 mg/kg produced a significant (P < 0.05) decrease in the blood glucose level (55.49%) at 8 h of treatment when compared with the control and was comparable with the reference drug, metformin. The extract was also subjected to antioxidant potentiality and brine shrimp lethality bioassays. The IC50 value of the extract was 693.0 mg/mL and the LC50 was 188.14 mg/mL.

Anahtar Kelimeler:

Key words: Antihyperglycemic, alloxan, Alocasia macrorrhizos, antioxidant activity, cytotoxicity, rhizome

Antihyperglycemic, antioxidant and cytotoxic activities of Alocasia macrorrhizos (Linn.) rhizomes extract

Keywords:

Key words: Antihyperglycemic, alloxan, Alocasia macrorrhizos, antioxidant activity, cytotoxicity, rhizome,

PDF

___

World Health Organization. Top Ten Causes of Death. Fact Sheet No. 310. WHO. Geneva; 2007. 2. King H, Aubert RE, Herman WH. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21: 1414-1431, 1998. 3. Wild S, Roglic G, Green A et al. Global prevalence of diabetes: estimates for 2000 and projections for 2030. Diabetes Care 27: 1047-1053, 2004.
Rahman MM, Islam MS, Ali MS et al. Antidiabetic and cytotoxic activities of methanolic extract of Tabernaemontana divaricata (L.) fl owers. Int J Drug Dev & Res 3: 270-276, 2011. 5. Pirart J. Diabetes mellitus and its degenerative complications: a prospective study of 4400 patients observed between 1947 and 1973. Diabetes Care 3: 97-107, 1977.
Prajapati ND. A Handbook of Medicinal Plants. Agrobios India. Jodhpur; 2003: p. 32.
Rahmatullah M, Al-Mahmud A, Rahman MA et al. An ethnomedicinal survey conducted amongst folk medicinal practitioners in the two southern districts of Noakhali and Feni, Bangladesh. Am Eurasian J Sustain Agric 5: 115-131, 2011. 11. Rahmatullah
M, Das AK, Mollik MAH et al. An ethnomedicinal
survey of Dhamrai Sub-district in Dhaka District, Bangladesh.
Am Eurasian J Sustain Agric 3: 881-888, 2009.
Wahid AM, Prafull BS, Ajinkya PM et al. Evaluation of antimicrobial activity of leaves of Alocasia indica Linn. Int J PharmTech Res 2: 327-333, 2010.
Mulla W, Kuchekar S, Th orat V et al. Antioxidant, Antinociceptive and anti-infl ammatory activities of ethanolic extract of leaves of Alocasia indica (Schott.). J Young Pharm 2: 137-143, 2010.
Mulla WA, Salunkhe VR, Kuchekar SB et al. Free radical scavenging activity of leaves of Alocasia indica (Linn). Indian J Pharm Sci 71: 303-307, 2009.
Patil BR, Bamane SH, Khadsare UR. In vitro protection of hepatocytes by Alocasia macrorrhiza leaf juice against CCL4 and Tylenol mediated hepatic injury. Int J Pharm Appl 2: 122- 127, 2011.
Mulla WA, Chopade AR, Bhise SB et al. Evaluation of antidiarrheal and in vitro antiprotozoal activities of extracts of leaves of Alocasia indica. Pharm Biol 49: 354-361, 2011.
Tien NQ, Ngoc PH, Minh PH et al. New ceramide from Alocasia macrorrhiza. Arch Pharm Res 27: 1020-1022, 2004.
Wang HX, Ng TB. Alocasin, an anti-fungal protein from rhizomes of the giant taro Alocasia macrorrhiza. Protein Expr Purif 28: 9-14, 2003.
Braca A, Tommasi ND, Bari LD et al. Antioxidant principles from Bauhinia terapotensis. J Nat Prod 64: 892-895, 2001.
Oyaizu M. Studies on product of browning reaction prepared from glucose amine. Jpn J Nutr 44: 307-315, 1986.
Meyer BN, Ferrigni NR, Putnam JE et al. Brine shrimp: a convenient general bioassay for active plants constituents. J Med Plant Res 45: 31-34, 1982.
Iriadam M, Musa D, Gümüşhan H et al. Eff ect of two Turkish medicinal plants Artemisia herba-alba and Teucrium polium on blood glucose levels and other biochemical parameters in rabbits. J Cell Mol Biol 5: 19-24, 2006.
Naeem F, Khan SH. Evaluation of the hypoglycemic and hypolipidemic activity of Butea monosperma fruit in diabetic human subjects. Turk J Biol 34: 189-197, 2010.
Pari L, Saravanan G. Antidiabetic eff ect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus. Comp Biochem Physiol Toxicol 131: 19-25, 2002.
Saravanan G, Pari L. Eff ect of Cogent db, an herbal drug on serum and tissue lipids metabolism in experimental hyperglycemic rats. Diabetes Obes Metab 5: 156-162, 2003.
Liu J, Head E, Gharib AM et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-α-lipoic acid. Proc Natl Acad Sci USA 99: 2356-2361, 2002.
Tanaka M, Kuie CW, Nagashima Y et al. Applications of antioxidative Maillard reaction products from histidine and glucose to sardine products. Nippon Suisan Gakkaishi 54: 1409-1414, 1988.
Mavi A, Yiğit N, Yiğit D et al. Antioxidant and antimicrobial activity of Turkish endemic Sonchus erzincanicus extracts. Turk J Biol 35: 243-250, 2011.
Cardellina JH, Fuller RW, Gamble WR et al. Evolving strategies for the selection dereplication and prioritization of antitumor and HIV-inhibitory natural products extracts. In: Bohlin L, Bruhn JG. eds. Bioassay Methods in Natural Product Research and Development. Kluwer Academic; 1999: pp. 25-37.