Long noncoding RNA PVT1: potential oncogene in the development of acute lymphoblastic leukemia

Emerging evidence shows that long noncoding RNAs (lncRNAs) participate in various cellular processes, and that

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  • Chen X, Gao G, Liu S, Yu L, Yan D, Yao X, Sun W, Han D, Dong H (2017). Long noncoding RNA PVT1 as a novel diagnostic biomarker and therapeutic target for melanoma. BioMed Res Int 2017: 7038579.
  • Colombo T, Farina L, Macino G, Paci P (2015). PVT1: a rising star among oncogenic long noncoding RNAs. BioMed Res Int 2015: 304208.
  • Cui D, Yu CH, Liu M, Xia QQ, Zhang YF, Jiang WL (2016). Long non-coding RNA PVT1 as a novel biomarker for diagnosis and prognosis of non-small cell lung cancer. Tumour Biol 37: 4127- 4134.
  • Delgado MD, León J (2010). Myc roles in hematopoiesis and leukemia. Genes Cancer 1: 605-616.
  • Garzon R, Volinia S, Papaioannou D, Nicolet D, Kohlschmidt J, Yan PS, Mrózek K, Bucci D, Carroll AJ, Baer MR (2014). Expression and prognostic impact of lncRNAs in acute myeloid leukemia. P Natl Acad Sci USA 111: 18679-18684.
  • Gu Z, Churchman M, Roberts K, Li Y, Liu Y, Harvey RC, McCastlain K, Reshmi SC, Payne-Turner D, Iacobucci I (2016). Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia. Nat Commun 7: 13331.
  • Guo K, Yao J, Yu Q, Li Z, Huang H, Cheng J, Wang Z, Zhu Y (2017). The expression pattern of long non-coding RNA PVT1 in tumor tissues and in extracellular vesicles of colorectal cancer correlates with cancer progression. Tumour Biol 39: 1010428317699122.
  • Hamilton MJ, Young MD, Sauer S, Martinez E (2015). The interplay of long non-coding RNAs and MYC in cancer. AIMS Biophys 2: 794.
  • Houshmand M, Soleimani M, Atashi A, Saglio G, Abdollahi M, Nikougoftar Zarif M (2017). Mimicking the acute myeloid leukemia niche for molecular study and drug screening. Tissue Eng Part C Methods 23: 72-85.
  • Huang C, Liu S, Wang H, Zhang Z, Yang Q, Gao F (2016). LncRNA PVT1 overexpression is a poor prognostic biomarker and regulates migration and invasion in small cell lung cancer. Am J Transl Res 8: 5025.
  • Huppi K, Pitt JJ, Wahlberg BM, Caplen NJ (2012). The 8q24 gene desert: an oasis of non-coding transcriptional activity. Front Genet 3: 69.
  • Jabbour E, O’Brien S, Konopleva M, Kantarjian H (2015). New insights into the pathophysiology and therapy of adult acute lymphoblastic leukemia. Cancer 121: 2517-2528.
  • Jeong KC, Ahn KO, Yang CH (2010). Small-molecule inhibitors of c-Myc transcriptional factor suppress proliferation and induce apoptosis of promyelocytic leukemia cell via cell cycle arrest. Mol Biosyst 6: 1503-1509.
  • Kamdje AHN, Krampera M (2011). Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment? Blood 118: 6506-6514.
  • Kong R, Zhang EB, Yin DD, You LH, Xu TP, Chen WM, Xia R, Wan L, Sun M, Wang ZX (2015). Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Mol Cancer 14: 82.
  • Kung JT, Colognori D, Lee JT (2013). Long noncoding RNAs: past, present, and future. Genetics 193: 651-669.
  • Li JR, Sun CH, Li W, Chao RF, Huang CC, Zhou XJ, Liu CC (2015). Cancer RNA-Seq Nexus: a database of phenotype-specific transcriptome profiling in cancer cells. Nucleic Acids Res 44: D944-D951.
  • Liu E, Liu Z, Zhou Y, Mi R, Wang D (2015). Overexpression of long non-coding RNA PVT1 in ovarian cancer cells promotes cisplatin resistance by regulating apoptotic pathways. Int J Clin Exp Med 8: 20565.
  • Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD, Girtman K, Mathew S, Ma J, Pounds SB (2007). Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 446: 758-764.
  • Pui CH (2000). Acute lymphoblastic leukemia in children. Curr Opin Oncol Curr Opin Oncol 12: 3-12.
  • Pui CH, Jeha S (2007). New therapeutic strategies for the treatment of acute lymphoblastic leukaemia. Nat Rev Drug Discov 6: 149- 165.
  • Pui CH, Robison LL, Look AT (2008). Acute lymphoblastic leukaemia. Lancet 371: 1030-1043.
  • Riquelme E, Suraokar MB, Rodriguez J, Mino B, Lin HY, Rice DC, Tsao A, Wistuba II (2014). Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. J Thorac Oncol 9: 998-1007.
  • Roderick JE, Tesell J, Shultz LD, Brehm MA, Greiner DL, Harris MH, Silverman LB, Sallan SE, Gutierrez A, Look AT (2014). c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood 123: 1040-1050.
  • Schmidt EV (1999). The role of c-myc in cellular growth control. Oncogene 18: 2988-2996.
  • Takahashi Y, Sawada G, Kurashige J, Uchi R, Matsumura T, Ueo H, Takano Y, Eguchi H, Sudo T, Sugimachi K (2014). Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. Br J Cancer 110: 164-171.
  • Tatar AS, Nagy-Simon T, Tomuleasa C, Boca S, Astilean S (2016). Nanomedicine approaches in acute lymphoblastic leukemia. J Control Release 238: 123-138.
  • Wallaert A, Durinck K, Taghon T, Van Vlierberghe P, Speleman F (2017). T-ALL and thymocytes: a message of noncoding RNAs. J Hematol Oncol 10: 66.
  • Wang BJ, Ding HW, Ma GA (2018). Long noncoding RNA PVT1 promotes melanoma progression via endogenous sponging MiR-26b. Oncol Res 26: 675-681.
  • Wang H, Mannava S, Grachtchouk V, Zhuang D, Soengas M, Gudkov A, Prochownik E, Nikiforov M (2008). c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle. Oncogene 27: 1905-1915.
  • Wei S, Wang K (2015). Long noncoding RNAs: pivotal regulators in acute myeloid leukemia. Exp Hematol Oncol 5: 30.
  • Wu BQ, Jiang Y, Zhu F, Sun DL, He XZ (2017). Long noncoding RNA PVT1 promotes EMT and cell proliferation and migration through downregulating p21 in pancreatic cancer cells. Technol Cancer Res Treat 16: 819-827.
  • Yang J, Yang X, Xiao L, Wang Y (2016). Long noncoding RNA PVT1 as a novel serum biomarker for detection of cervical cancer. Eur Rev Med Pharmacol Sci 20: 3980-3986.
  • Zeng C, Yu X, Lai J, Yang L, Chen S, Li Y (2015). Overexpression of the long non-coding RNA PVT1 is correlated with leukemic cell proliferation in acute promyelocytic leukemia. J Hematol Oncol 8: 126.
  • Zhou Q, Chen F, Zhao J, Li B, Liang Y, Pan W, Zhang S, Wang X, Zheng D (2016). Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195. Oncotarget 7: 82620.
  • Zörnig M, Evan GI (1996). Cell cycle: on target with Myc. Curr Biol 6: 1553-1556.