EMRE AKSOY, Sefa AYTEN, Bayram Ali YERLİKAYA, Buasimuhan ABUDUREYİMU

Bitkilerde Hücre İçi Demir Dağıtım Mekanizmaları

Temel mikro-besin elementi demir (Fe) bitkide önemli rolleri bulunan birçok metalloproteinin aktif bölgesinde kofaktör olarak yer alır. Öte yandan aşırı reaktif olduğundan, hücre içerisinde fazla birikimi reaktif oksijen türlerinin üretimini tetikleyerek hücre ölümlerine neden olur. Dolayısıyla hücre içerisindeki demir homeostazı bitki gelişimi için çok önemlidir. Bitkiler demiri kök içerisine aldıktan sonra hücre içi kompartmanlara dağıtımını yaparlar. Hücre içi demir taşınımı ve dolayısıyla hücresel demir homeostazı farklı membran protein ailelerinin senkronize kontrolü sayesinde yürütülmektedir. Bu membran proteinlerinin demir eksikliği altında ifade seviyelerinin arttığı keşfedilmiştir. Bu taşıyıcıların görev ve regülasyonlarının irdelenmesi bitkilerdeki demir alım ve dağıtım mekanizmalarının anlaşılması açısından çok önemlidir. Bu yüzden bu derlemede hücre içerisine alınan demirin organellere dağıtımından sorumlu taşıyıcılar ile bu taşıyıcılar hakkındaki güncel gelişmelerden bahsedilmektedir.

Subcellular Iron Localization Mechanisms in Plants

The basic micro-nutrient element iron (Fe) is present as a cofactor in the active sites of many metalloproteins with important roles in the plant. On the other hand, since it is excessively reactive, excess accumulation in the cell triggers the production of reactive oxygen species, leading to cell death. Therefore, iron homeostasis in the cell is very important for plant growth. Once uptake into the roots, iron is distributed to the subcellular compartments. Subcellular iron transport and hence cellular iron homeostasis is carried out through synchronous control of different membrane protein families. It has been discovered that expression levels of these membrane proteins increase under iron deficiency. Examination of the tasks and regulations of these carriers is very important in terms of understanding the iron intake and distribution mechanisms in plants. Therefore, in this review, the transporters responsible for the uptake of iron into the cell and its subcellular distribution between organelles will be discussed with an emphasis on the current developments about these transporters.

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