Akut REM Uyku Yoksunluğu Oluşturulan Sıçanlarda Uzun dönem Ilımlı Egzersizin Depresif/Anksiyete Benzeri Davranış Üzerine Etkisi

Uyku iç ve dış faktörlerden etkilenen, belli dönemlerinde beynin uyanıklıktaki kadar aktif olduğu fizyolojik bir süreçtir. REM uyku yoksunluğunda psikiyatrik bozuklukların daha sık görülmesi nedeniyle ruhsal dinlenmeyi sağlayan bir dönem olduğu ve depresyon/anksiyete benzeri durumlara sebep olduğu literatürde belirtilmiştir. Fiziksel egzersizin depresif/anksiyete üzerine yararlı olabileceğine dair literatürde çalışmalar bulunmaktadır. Ama uygulanan fiziksel egzersizin ve uyku yoksunluğunun süresi ve şiddeti sonuçları etkilemektedir. Bu nedenle çalışmamızda uzun dönem egzersizin akut REM uyku yoksunluğu oluşturulmuş sıçanlarda depresyon/anksiyete davranışına olan etkisi incelenmiştir. Sıçanlar kontrol (K), egzersiz (E), REM uyku yoksunluğu (UY) ve egzersiz + REM uyku yoksunluğu (E+UY) olmak üzere (n=7) bölünmüştür. REM uyku yoksunluğu oluştururken sıçanlar 48 saatlik bir dönemde uyku yoksunluğu düzeneğinde barındırılmışlardır. Egzersiz uygulaması 15, 30, 45 ve 60 dakika olmak üzere 4 hafta boyunca treadmill ile gerçekleştirilmiştir. Depresif /anksiyete davranışları açık alan ve yükseltilmiş plus maze ile değerlendirilmiştir. Uyku yoksunluğu grubunun açık alan testinde daha az mesafe kat ettiği gösterilmiştir. Yükseltilmiş plus maze testinde yine uyku yoksunluğu grubundaki sıçanların diğer gruplara göre açık kolda daha az süre geçirdikleri ve bu kola giriş çıkış sayılarının da azaldığı gözlemlenmiştir. Davranış testi bulguları, uyku yoksunluğunun oluşturduğu depresif/anksiyete benzeri etkilerin ılımlı treadmill egzersizi tarafından azaltıldığını göstermektedir.

The Effect of Long Term Moderate Exercise on Depressive / Anxiety-Like Behavior in Rats with Acute REM Sleep Deprivation

Sleep is a physiological process that influenced by internal and external factors and brain is as active as waking in certain periods. REM sleep is demonstrated in the literature that provides psychological relaxation due to more frequent occurrence of psychiatric disorders in sleep deprivation and causes depression / anxiety-like situations. There are studies in the literature indicate that physical exercise may be useful on depressive / anxiety. However, the duration and physical severity of the physical exercise and sleep deprivation affects the results. For this reason, we investigated the effect of long-term exercise on depression / anxiety behavior on acute REM sleep deprived rats. Rats were divided into control (C), exercise (E), REM sleep deprivation (SD) and exercise + REM sleep deprivation (E + SD) (n = 7). For developing REM sleep deprivation, rats were kept in a sleep deprivation tank during a 48-hour period. Exercise was performed with treadmill for 15, 30, 45 and 60 minutes for 4 weeks. Depressive / anxiety behaviors were assessed with open field and elevated plus maze tests. It has been shown that the sleep deprivation group takes less distance in the open field test. It was observed that in the elevated plus maze test, the rats in the sleep deprivation group spent less time on the open-arm compared to the other groups, and the number of entries and exits in this group also decreased. Behavioral test findings show that depressive / anxiety-like effects of sleep deprivation are reduced by moderate treadmill exercise.

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