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Hodgkin lenfomalı bir hastada varyant Guillain-Barré sendromu: AMSAN

Lenfomalar, lenfoid kökenli hücrelerin anormal çoğalması sonucuortaya çıkan tümörlerdir. Hodgkin lenfomada nörolojik bulgular; sinir sistemine yayılım, kemoterapi ve radyoterapiye ikincil, kitle basısı sonucu, enfeksiyon ile ilişkili olarak ya da paraneoplastik sendromşeklinde ortaya çıkabilir. Paraneoplastik nörolojik sendromlar Hodgkinve Hodgkin-dışı lenfomalarda nadiren görülür. Hodgkin lenfomadagörülen serebellar sendrom ve dermato-polimiyozit dışında diğer paraneoplastik nörolojik bulgular olgu bildirimi düzeyindedir. Bu yazıdaHodgkin lenfoma tanısı ile izlediğimiz, tedavi başlama aşamasındaiken her iki alt ekstremitelerden başlayan güçsüzlük ve duyu kaybı gelişen, klinik bulgularına ve yapılan tetkiklerine dayanarak Guillain-Barrésendromunun bir alt tipi olan akut motor duyusal aksonal nöropati tanısı alan bir olgu sunulmuştur.

Variant Guillain-Barré syndrome in a patient with Hodgkin lymphoma: AMSAN

Lymphomas are solid tumors characterized by the malignant proliferation of lymphoid cells. Neurologic signs encountered in patients with Hodgkin’s lymphoma can be due to the direct spread of tumor to the nervous system, secondary to chemotherapy or radiation, secondary to tumor mass compression, infectious causes and paraneoplastic syndromes. Paraneoplastic neurologic syndromes are rarely encountered in patients with Hodgkin’s lymphoma and non-Hodgkin’s lymphoma. Except for paraneoplastic cerebellar degeneration in Hodgkin’s lymphoma and dermato/polymyositis in both Hodgkin’s lymphoma and non-Hodgkin’s lymphoma, other paraneoplastic syndromes are uncommon and have only been reported as isolated case reports or short series. Here, we present a patient with Hodgkin’s lymphoma with symptoms of bilateral lower extremity weakness and loss of sensation before the start of therapy, who was eventually diagnosed as having motor and sensory axonal neuropathy.

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