Mahendra Sampurna, Dina Angelika, Martono Tri Utomo, Nur Aisiyah Wijaya, Budiono Budiono, Firas Farisi Alkaff, Roedi Irawan, Risa Etika

Düşük doğum tartılı bebeklerde enteral glutamin desteğinin kilo alma modelleri ve dışkıdaki salgısal immünoglubulin A düzeyleri üzerinde etkisi

Amaç: Glutamin optimal hücre çoğalması ve immün sistem için veözellikle bağırsaklarda bulunan enterositlerde mukozal immün yanıtlar için gereklidir. Düşük doğum ağırlığı, bebekleri glutamin eksikliğine karşı duyarlı kılar, çünkü yaşamın ilk haftası içinde beslenmekısıtlıdır. Bu çalışmanın amacı enteral glutamin desteğinin kilo almamodelleri ve dışkıdaki salgısal immünoglobulin A üzerindeki etkilerini belirlemektir.Gereç ve Yöntemler: Bu çalışma, çift-kör, randomize, kontrollü bir çalışmadır. Bebekler, randomize olarak glutamin grubuna ve plasebogrubuna ayrılmışlardır. Glutamin grubuna 14 gün süre ile 400 mg/kg/gün glutamin desteği verilmiştir ve plasebo grubuna 14 gün süre ile400 mg/kg/gün glükoz verilmiştir. Bebekler 30 gün süre ile gözlenmişlerdir. Çalışma esnasında, doğum ağırlığına geri dönüş, kilo almahızı ve dışkıdaki salgısal immünoglobulin A düzeyleri izlenmiştir.Bulgular: Otuz yedi düşük doğum ağırlıklı bebek randomize olarakglutamin ve plasebo gruplarına ayrılmışlardır. Glutamin grubunda,doğum ağırlığına geri dönme süresi daha kısa (8,1±0,9 vs. 11,0±1,6gün) ve kilo alma hızı daha yüksek (20,0±1,8 vs. 15,5±2,2 g/kg/gün) bulunmuştur (p

Effect of enteral glutamine supplementation for low-birth-weight infants on weight gain patterns and levels of fecal secretory immunoglobulin A

Aim: Glutamine is needed for optimal cell growth and for the immune system, especially in the enterocytes of gut mucosal immune responses. Low birth weight makes infants susceptible to glutamine depletion because nutrition is limited in the first week of life. To determine the effect of enteral glutamine supplementation on weight gain patterns and fecal secretory immunoglobulin A. Material and Methods: This study is a double-blind, randomized controlled trial. Infants were randomly assigned to the glutamine group and placebo group. The glutamine group was supplemented with glutamine 400 mg/kg/day for 14 days, and placebo group received glucose 400 mg/kg/day for 14 days. The infants were observed for 30 days. Return-to-birth-weight, weight gain velocity, and fecal secretory immunoglobulin A levels were monitored during the study. Results: Thirty-seven low-birth-weight infants were randomly assigned to the glutamine and placebo groups. The glutamine group had a shorter return-to-birth-weight time than the placebo group (8.1±0.9 vs. 11.0±1.6 days) and faster weight gain velocity (20.0±1.8 vs. 15.5±2.2 g/kg/day) (p

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