Ayhan SÖĞÜT, Peyker TEMİZ, Şule YILDIRIM, Serkan ÖZEN, Hasan YÜKSEL, Özge YILMAZ

Amoksisilin-klavulanata bağlı akut yaygın ekzantematöz püstüloz

Akut yaygın ekzantematöz püstüloz akut başlangıçlı püstüler döküntü ile belirgin nadir görülen bir hastalıktır. Amoksisilin-klavulanat kullanımı sonrası gelişen bir akut yaygın ekzantematöz püstüloz olgusu sunulmaktadır. Hasta ilaç kullanımı sonrasında püstüler, kaşıntılı döküntüler ile başvurdu ve tanısı patolojik bulgularla doğrulandı. Çeşitli klinik görünümlere yol açan bu durum, püstüler dermatozların ayırıcı tanısında mutlaka düşünülmelidir.

Acute generalized exanthematous pustulosis due to amoxicilline-clavulanatet

Acute generalized exanthematous pustulosis is an uncommon clinical condition characterized by an acute onset of pustular eruptions. A case of acute generalized exanthematous pustulosis after the use of amoxicilline-clavulanate is presented. The patient presented with pustular and pruritic eruptions after use of drug. The diagnosis was confirmed with pathological data. This condition leading to various clinical manifestations should be thought in the differential diagnosis of pustular dermatosis.

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1. Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI (eds) Fitzpatrick's Dermatology in General Medicine. 6th ed. New York: McGraw-Hill, 2003: 625-7.
2. Beylot C, Bioulac P, Doutre MS. Acute generalized exanthematic pustuloses (four cases). Ann Dermatol Venereol 1980; 107: 37-48.
3. Roujeau JC. Neutrophilic drug eruption. Clin Dermatol 2000; 18: 331-7.
4. Salvo F, Polimeni G, Moretti U, et al. Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: data from spontaneous reporting in Italy. J Antimicrob Chemother 2007; 60: 121-6.
5. Rallis E, Balatsouras DG, Kouskoukis C, Verros C, Homsioglou E. Drug eruptions in children with ENT infections. Int J Pediatr Otorhinolaryngol 2006; 70: 53-7.
6. Romano A, Blanca M, Torres MJ et al. Diagnosis of nonimmediate reactions to, beta-lactam antibiotics. Allergy 2004; 59: 1153-60.
7. Britschgi M, Steiner UC, Schmid S, et al. T-cell involvement in drug induced acute generalized exanthematous pustulosis. J Clin Invest 2001; 107: 1433-41.
8. Padial MA, Alvarez-Ferreira J, Tapia B, et al. Acute generalized exanthematous pustulosis associated with pseudoephedrine. Br J Dermatol 2004; 150: 139-42.
9. Baker H, Ryan TJ. Generalized pustular psoriasis. A clinical and epidemiological study of 104 cases. Br J Dermatol 1968; 80: 771-93.
10. Beylot C, Doutre MS, Beylot-Barry M. Acute generalized exanthematous pustulosis. Semin Cutan Med Surg 1996; 15: 244-9.
11. Roujeau JC, Bioulac-Sage P, Bourseau C, et al. Acute generalized exanthematous pustulosis. Analysis of 63 cases. Arch Dermatol 1991; 127: 1333 8.
12. Belda JW, Ferolla ACJ. Acute generalized exanthematous pustulosis (AGEP). Case report. Rev Inst Med Trop Sao Paulo 2005; 47: 171-6.
13. Fabre B, Albès B, Belhadjali H, Bazex J. Pustulose exanthématique aiguë généralisée induite par le fluconazole. Ann Dermatol Venereol 2002; 129: 294-7.
14. Dolar N, Tüzün Y. Akut generalize ekzantematöz püstüloz. Dermatose 2005; 44: 173-5.
15. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP)- a clinical reaction pattern. J Cutan Pathol 2001; 28: 113-9.