Türkan GÜRSU, Güldeniz DESTELİ, Ali AYHAN

HUMAN PAPİLLOMA VİRÜS AŞILARININ KOMPLİKASYONLARI

HPV tip 16,18 e karşı etkili bivalan ve HPV tip 6,11,16,18 e karşı etkili kuadrivalan HPV aşılarının koruyuculuğu birçok çalışma ile kanıtlanmıştır. PATRICIA çalışması ile diğer HPV tiplerine karşı da çapraz reaksiyonlar ile aşıların koruyucu olduğu bildirilmiştir. Bivalan aşının HPV 18’e karşı koruyuculuğu daha baskındır. Her iki aşının etkileri ve komplikasyonları birçok çalışma ve vaka serileri ile tartışılmış, EINSTEIN’ın çalışmasında aşıların immun cevap oluşturabilmeleri ve komplikasyonları incelenmiştir. Literatürde erken dönemde hipersensitiveite reaksiyonları, lokal etkiler ve uzun dönem etkiler arasında demiyelinizan hastalıklar, otoimmun tiroiditler, endokrin ve sistemik hastalıklar araştırılmıştır. Biz bu çalışmamızda HPV aşılarının kısa ve uzun dönem komplikasyonlarını inceledik

Anahtar Kelimeler:

HPV, Serviks kanseri, HPV aşıları, Aşı komplikasyonları

COMPLICATIONS OF HUMAN PAPILLOMA VIRUS VACCINES

HPV 16/18 bivalent vaccines and HPV 6/11/16/18 quadrivalent vaccines are protective vaccines against cervical carcinoma as prooved by many studies so far. The PATRICIA study revealed that due to cross protective effect against other types of viruses, the preventative field of current vaccines’ are enlarged. Bivalent vaccines show dominant protection against HPV 18 than quadrivalent vaccines. The effects and side effects of both vaccines are discussed in large case series till this day. EINSTEIN studied vaccines in aspect of creation of immunogenic response and related complications . In the literature, short term complications are grouped as hypersensitivity reactions, local side effects, and among long term complications there are demyelinizating diseases, autoimmune thyroditis, endocrinopathies and other systemic diseases. In this study we rewieved current short and long term complications of HPV vaccines.

Keywords:

HPV, Cervix cancer, HPV vaccine, Vaccine complications,

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