Mustafa ERTEK, Etem ÖZKAYA, Alper AKÇALI, Ahmet ÇARHAN, Yavuz UYAR

Türkiye'de kene ısırığı öykülü olgularda Tıck- borne encephalitis virüsünün seroprevalansı

Amaç:Tick-borne encephalitis (TBE), santral sinir sisteminin bir viral enfeksiyöz hastalığıdır .Flaviviridea ailesinden Tick-borne encephalitis virüsü (TBEV) tarafından oluşturulmaktadır . TBEtablosu, sıklıkla Ixodes ricinus türü kenenin ısırmasıyla oluşmaktadır . TBE vakaları genellikle keneaktivitesinin yüksek olduğu dönemlerde oluşmaktadır . Bu seroepidemiyolojik çalışma ileülkemizde TBE görülme sıklığının ortaya konulması amaçlanmıştır . Yöntem: Çalışmaya, 2006 yılı içinde kene ısırma öyküsü olan vakaların RSHM VirolojiLaboratuvarı'na gönderilmiş serum örnekleri dahil edilmiştir . Serumlar çalışma gününe kadar -80°C'de saklanmıştır . 278 kişiye ait serum örneğinde anti-TBEV IgG antikorları ELISA metodu ilearaştırılmıştır .Bulgular: Çalışmaya alınanların 145 (% 52.2)'i erkek 133 (% 47.8)'ü kadındır . Örneklerin 133 (%47.8)'ü İç Anadolu; 122 (%43.9)'si Karadeniz; 8 (%2.9)'i Marmara; 6 (%2.2)'sı Doğu Anadolu; 6(%2.2)'sı Ege ve 3 (%1.0)'ü Güney Doğu Anadolu Bölgesi'nden gelmiştir . TBE IgG antikoru 4 (% 1.4)vakada pozitif bulunmuştur . Bu olguların biri hariç hepsi İç Anadolu Bölgesi'ndendir .Sonuç: Kene populasyonu bakımından zengin olan ve bu populasyonda Ixodes ricinus türü debulunan ülkemizde TBE konusunda klinisyenlerimizin dikkatli olması ve bu konuda daha genişseroepidemiyolojik çalışmalar yapılması gerekmektedir .

Seroprevalence of Tick-borne encephalitis virus (TBEV) among cases with Tick bite history in Turkey

Objective: Tick-borne encephalitis (TBE) is a viral infection of central nervous system. Thecausative agent is Tick-borne encephalitis virus (TBEV) within Flaviviridea family. The clinicalsymptoms often start after biting of Ixodes ricinus ticks. The TBE cases generally occur when thetick activities increase. This seroepidemiological study aimed to investigate the TBE in Turkey. Method: The serum samples of tick bite cases sent to Refik Saydam Hygiene Centre, Virology0 Laboratory in 2006 included in this study. The sera kept at -80 C till testing. Anti-TBEV IgG and IgMantibodies were investigated using ELISA in two hundred seventy eight (278) serum samples. Results: Of the tested samples, 52.2 %and 47.8 % were from male and female cases,respectively. The regional distribution of these samples are 133 (47.8%) from Central Anatolia,122 (43.9 %) from Black Sea, 8 (2.9 %) from Marmara; 6 (2.2 %) from East Anatolia, 6 (2.2 %) fromAegean and 3 (1.0 %) from Southeastern. Anti-TBE IgG was found positive in 4 (1.4 %) samples. Thepositives for anti-TBE IgG, except one, was from Central Anatolia. Conclusion: Turkey is a rich country for different population of ticks including Ixodes ricinus.Thus, clinicians should take consideration about TBE and broad seroepidemiologicalinvestigations should be carried out.

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