Bakterilerin antibiyotiklere duyarlılığına antioksidanların etkisinin incelenmesi

Amaç: Bu araştırmada farklı konsantrasyonlardaki antioksidanların (askorbik asit, emokipin, tokoferol asetat ve iyonol); bakterilerin antibiyotik hassasiyeti üzerine etkisi çalışılmıştır .Yöntem:Solunum tipleri farklı olan bakterilerden aerob olarak Pseudomonas aeruginosa veakültatif anaerob olarak Escherichia coli kullanılmış; mikroorganizmaların antibiyotik hassaiyeti Minimal İnhibisyon Konsantrasyonu (MİK) olarak dilüsyon testi ile belirlenmiştir .Bulgular: Değişik konsantrasyonlardaki antioksidanlar P .aeruginosa'nın polimiksin ve treptomisine duyarlılığını artırırken, E.coli'nin duyarlılığını azaltmıştır .Sonuç: Antibiyotik duyarlılığına antioksidanların etkisi bakterinin solunum tipine dayanmaktadır .

The effect of antioxidants on antibiotic sensitivity of bacteria

Objective: The effect of different concentrations of antioxidants (ascorbic acid, emoxipin,tocopherol acetate and ionol) on antibiotic sensitivity of bacteria was studied.Method: Bacteria belong to different respiration types: Pseudomonas aeruginosa as aerobeand Escherichia coli as facultative anaerobe were used. Antibiotic sensitivity of microorganismswas determined as minimum inhibitory concentration (MIC) by dilution test.Results: Different concentrations of antioxidants increased the sensitivity of P .aeruginosabut decreased the sensitivity of E.coli to polimyxine and streptomycin.Conclusion: The effect of antioxidants on antibiotic sensitivity depends on respiration typeof bacteria.

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