Unusual variants of primary malignant esophageal tumors
Amaç: Bu çalışmada özofagusun nadir görülen malign tümörleri olan bir grup hastanın özellikleri literatür eşliğinde tartışıldı.Ça lış ma pla nı: Atatürk Üniversitesi Tıp Fakültesi Göğüs Cerrahisi Bölümünde Ocak 2000 - Mart 2014 tarihleri arasında özofagus kanseri tanısı konulan 953 hasta içinden nadir primer malign özofagus tümörü olan 37 hasta (14 erkek, 23 kadın; ort. yaş 63.7±12.1 yıl; dağılım 20-87 yıl) çalışmaya dahil edildi. Hastalar yaş, cinsiyet, histopatolojik tip, tümörün yerleşim yeri, uygulanan tedavi, tümör evresi ve sağ kalıma göre retrospektif olarak değerlendirildi. Tanı ve evreleme amacıyla özofagoskopi, tomografi, baryumlu özofagus grafisi, batın ultrasonografisi ve pozitron emisyon tomografisi ve bilgisayarlı tomografi uygulandı.Bul gu lar: Hastaların 19'unda adenoskuamöz hücreli karsinom, dokuzunda nöroendokrin hücreli karsinom, dördünde bazaloid skuamöz hücreli karsinom, ikisinde karsinosarkom, birinde mukoepidermoid karsinom, birinde adenoid kistik karsinom ve birinde leiyomyosarkom vardı. Sınırlı hastalık olmasından dolayı 19 hastaya özofajektomi uygulandı. Özofajektomi uygulanan hastalarda sağkalım oranı daha iyi idi (p
Özofagusun primer malign tümörlerinin nadir varyantları
Background: This study aims to discuss the features of a group of patients with rare malignant tumors of the esophagus in the light of the literature.Methods: Of a total of 953 patients diagnosed with esophageal cancer between January 2000 and March 2014 in Atatürk University, Faculty of Medicine, Department of Thoracic Surgery, 37 patients (14 males, 23 females; mean age 63.7±12.1 years; range 20 to 87 years) with rare primary malignant tumors of the esophagus were included in the study. We assessed the patients retrospectively according to age, sex, histological type, tumor localization, treatment administered, tumor stage, and survival. Esophagoscopy, tomography, esophageal barium X-ray, abdominal ultrasonography, and positron emission tomography and computed tomography were performed for diagnosis and staging purposes.Results: Of the patients, 19 had adenosquamous cell carcinoma, nine had neuroendocrine cell carcinoma, four had basaloid squamous cell carcinoma, two had carcinosarcoma, one had mucoepidermoid carcinoma, one had adenoid cystic carcinoma, and one had leiomyosarcoma. Due to limited disease, esophagectomy was performed to 19 patients. Survival rate was better in patients who were performed esophagectomy (p
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- Szumilo J, Dabrowski A. Primary esophageal malignant melanoma. Pol J Pathol 2011;62:148-51.
- Chen S, Chen Y, Yang J, Yang W, Weng H, Li H, et al. Primary mucoepidermoid carcinoma of the esophagus. J Thorac Oncol 2011;6:1426-31.
- Chen WS, Zheng XL, Jin L, Pan XJ, Ye MF. Novel diagnosis and treatment of esophageal granular cell tumor: report of 14 cases and review of the literature. Ann Thorac Surg 2014;97:296-302.
- Maru DM, Khurana H, Rashid A, Correa AM, Anandasabapathy S, Krishnan S, et al. Retrospective study of clinicopathologic features and prognosis of high-grade neuroendocrine carcinoma of the esophagus. Am J Surg Pathol 2008;32:1404-11. 5. Francioni F,
- Tsagkaropoulos S, Telha V,
- Cancer Res Clin Oncol 2012;138:1165-71.
- Zia-ur-Rehman, Pal I, Ahmed Z, Qureshi A. Carcinosarcoma of the esophagus. J Coll Physicians Surg Pak 2010;20:282-4.
- Gaur DS, Kishore S, Saini S, Pathak VP. Carcinosarcoma of the oesophagus. Singapore Med J 2008;49:283-5.
- Iyomasa S, Kato H, Tachimori Y, Watanabe H, Yamaguchi H, Itabashi M. Carcinosarcoma of the esophagus: a twenty- case study. Jpn J Clin Oncol 1990;20:99-106.
- Fegelman E, Law SY, Fok M, Lam KY, Loke SL, Ma LT, et al. Squamous cell carcinoma of the esophagus with mucin- secreting component. Mucoepidermoid carcinoma. J Thorac Cardiovasc Surg 1994;107:62-7.
- Matsufuji H, Kuwano H, Ueo H, Sugimachi K, Inokuchi K. Mucoepidermoid carcinoma of the esophagus--a case report. Jpn J Surg 1985;15:55-9.
- Ozawa S, Ando N, Shinozawa Y, Ohmori T, Kase K, Sato T, et al. Two cases of resected esophageal mucoepidermoid carcinoma. Jpn J Surg 1989;19:86-92.
- Koide N, Hamanaka K, Igarashi J, Hanazaki K, Adachi W, Hosaka S, et al. Co-occurrence of mucoepidermoid carcinoma and squamous cell carcinoma of the esophagus: report of a case. Surg Today 2000;30:636-42.
- Turkyilmaz A, Eroglu A, Gursan N. Muco-epidermoid carcinoma of the oesophagus: a case report. Acta Chir Belg 2009;109:416-8.
- Karaoglanoglu N, Eroglu A, Turkyilmaz A, Gursan N. Oesophageal adenoid cystic carcinoma and its management options. Int J Clin Pract 2005;59:1101-3.
- Petursson SR. Adenoid cystic carcinoma of the esophagus. Complete response to combination chemotherapy. Cancer 1986;57:1464-7.
- Na YJ, Shim KN, Kang MJ, Jung JM, Ha CY, Jung HS, et al. Primary esophageal adenoid cystic carcinoma. Gut Liver 2007;1:178-81.
- Goldberg A. Less common malignant tumors of the esophagus. In: Shields TW, editor. General Thoracic Surgery. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2009. p. 2041-50.
- Dougherty MJ, Compton C, Talbert M, Wood WC. Sarcomas of the gastrointestinal tract. Separation into favorable and unfavorable prognostic groups by mitotic count. Ann Surg 1991;214:569-74.
- Eroğlu A, Kürkçüoğlu C, Karaoğlanoğlu N, Erdoğan F, Polat P. Simultaneous leiomyosarcoma and squamous cell carcinoma of the esophagus: report of a new case. Dis Esophagus 2001;14:245-6.
- Ovens JM, Russell WO. Concurrent leiomyosarcoma and squamous carcinoma of the esophagus. AMA Arch Pathol 1951;51:560-4.