Evaluation of preoperative neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients undergoing major vascular surgery

Amaç: Bu çalışmada majör vasküler cerrahi yapılanhastalarda ameliyat öncesi nötrofil-lenfosit oranının(NLR) ve trombosit-lenfosit oranının (PLR) prognostik bir rolü olup olmadığı ve sağkalım ile olan ilişkisi araştırıldı. Çalışma planı: Haziran 2005 ve Aralık 2012 tarihleri arasında majör vasküler cerrahi yapılan 838 ardışık hasta(593 erkek, 245 kadın; ort. yaş 63 yıl; dağılım 10-99 yıl) çalışmaya alındı. Mutlak nötrofil ve trombosit sayısının mutlak lenfosit sayısına bölünmesi ile NLR ve PLR hesaplandı. Bulg ul ar: Ortalama mortalite riski NLR ≥5 olan has-talarda 2.85 (dağılım 1.67-4.87), PLR ≥200 olan hasta-larda 3.76 (dağılım 2.31-6.12) idi. Diyabet hastalarınınoranı, NLR ≥5 (%63.7; p= 0.000) ve PLR ≥200 olanhastalarda (%53.8; p= 0.003) anlamlı düzeyde daha yüksekti. Sonuç: Çalışma bulgularımız artmış NLR ve PLR’ninameliyat sonrası mortalite ile doğrudan, sağkalım ile ters ilişkili olduğunu ve diyabetli hastaların daha yüksek riskaltında olduğunu gösterdi.

Majör vasküler cerrahi yapılan hastalarda ameliyat öncesi nötrofil-lenfosit oranı ve trombosit-lenfosit oranının değerlendirilmesi

Background: This study aims to examine whetherpreoperative neutrophil-lymphocyte ratio (NLR) andplatelet-lymphocyte ratio (PLR) had a preoperativeprognostic role and its association with survival in patientsundergoing major vascular surgery.Methods: Between June 2005 and December 2012, 838consecutive patients (593 males, 245 females; mean age 63years; range, 10 to 99 years) who underwent major vascularsurgery in our clinic were included. The NLR and PLRwere determined by dividing the absolute neutrophil andplatelet count by the absolute lymphocyte count.Results: The mean mortality risk was 2.85 (range 1.67-4.87) in patients with a NLR of ≥5 and 3.76 (range 2.31- 6.12) in patients with a PLR of ≥200. The proportion ofdiabetic patients was significantly higher for patients withNLR ≥5 (63.7%; p= 0.000) and PLR ≥200 (%53.8; p=0.003).Conclusion: Our study results showed that increased levelsof NLR and PLR were directly correlated with mortalityand inversely correlated with survival in the postoperativeperiod and that diabetic patients were under a higher risk.

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