Sami BAYRAM, Abdülkadir ERCAN, Davit SABA, Murat BİÇER, Gencehan KUMTEPE, şık ŞENKAYA, Orçun GÜRBÜZ

Evaluation of polylactide film for prevention of pericardial adhesion in a rabbit model

Amaç: Bu çalışmada pelvik yapışıklıkları önlemedeetkinliği kanıtlanmış biyoemilebilir polilaktid bariyerinameliyat sonrası perikardiyal yapışıklıkları önlemedekietkinliği bir hayvan modelinde değerlendirildi.Çalışmaplanı: Kırk Yeni Zelanda beyaz tavşanı eşitolarak kontrol ve tedavi gruplarına ayrıldı. Deneklere solanterior torakotomi ve parsiyel perikardiyektomi sonrasıepikardiyal abrazyon uygulandı. Kontrol gruplarında(grup 1 ve 2) retrosternal yapışıklıklara izin vermekiçin perikard açık bırakıldı. Tedavi gruplarında ise(grup 3 ve 4) perikardiyal defekt 0.02 mm biyoemilebilirpolilaktid bariyer ile kapatıldı. Ameliyat sonrasımakroskopik ve mikroskopik değerlendirmeler gruplarhakkında bilgisi olmayan değerlendirmeciler tarafındangrup 1 ve 3te üçüncü haftanın sonunda, grup 2 ve 4teise altıncı haftanın sonunda yapıldı.Bul gu lar: Makroskopik ve histopatolojik değerlendirmelerkontrol ve tedavi grupları arasında adezyon gelişimiaçısından anlamlı farklılık olmadığını gösterdi. Ancakpolilaktid bariyer tedavi gruplarında mezotelyum benzerihücre tabakasının gelişimini destekledi.Sonuç: Polilaktid bariyer mezotel hücre tabakasınınrejenerasyonuna yardımcı olsa da perikardiyalyapışıklıkların gelişimini önlememektedir.

Perikardiyal adezyonların önlenmesinde polilaktid bariyerin bir tavşan modelinde değerlendirilmesi

Background: This study aims to evaluate the efficacy ofa bioabsorbable polylactide film, which was proven to beeffective in preventing pelvic adhesions, in prevention ofpostoperative pericardial adhesions in an animal model. Methods: Forty New Zealand white rabbits were dividedequally into control and treatment groups. Subjectswere performed left anterior thoracotomy and partialpericardiectomy followed by epicardial abrasion. Incontrol groups (group 1 and 2), the pericardium wasleft open to allow retrosternal adhesions. In treatmentgroups (group 3 and 4), the pericardial defect wasclosed with 0.02 mm bioabsorbable polylactide film.Postoperative macroscopic and microscopic evaluationswere made by the same blinded observers at the end ofthe third week in group 1 and 3, and at the end of thesixth week in group 2 and 4. Results: Macroscopic and histopathologic examinationsrevealed no significant differences between control andtreatment groups in terms of adhesion formation. However,polylactide film supported the growth of a mesothelium- like layer in the treatment groups. Conclusion: Although polylactide film assists in theregeneration of mesothelial cells layer, it does not preventthe development of pericardial adhesions.

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