Akut solunum sıkıntısı sendromu

Akut solunum sıkıntısı sendromu (ARDS) ve onun daha az ciddi formu olan akut akciğer hasarı (AAH) 1960'lı yıllardan beri değişik isim ve tanımlar altında bilinmektedir. Sendromun etyopatogenezi geniş şekilde araştırılmıştır, ancak tıptaki gelişmelere rağmen tedavi seçenekleri ve prognozun hala iyileştirilmeye ihtiyacı vardır. Tedavi girişimlerinin temelini mekanik ventilasyon oluşturmakta olup, yeni modlar ve ventilasyon stratejileri umut vaad etmektedir. Maalesef mevcut farmakolojik ajanların hiçbirinin mortaliteyi azalttığı gösterilmemiştir. Ancak bazı belirli hasta altgruplarıyla yapılan çalışmalar kişiselleştirilmiş tedavi seçeneklerinin genelleyici yaklaşıma göre daha iyi sonuçlar ortaya koyacağını göstermektedir.

Acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) and its less serious form acute lung injury (ALI) have been recognized since 1960s under different names and descriptions. The etiopathogenesis of the syndrome has been studied widely but despite of developments in medicine, treatment choices and the prognosis still need to be improved. Mechanical ventilation is the mainstay of therapeutic interventions and new modes and ventilation strategies seem promising. Unfortunately none of the pharmacological agents available is shown to reduce mortality. However, studies concerning with some certain subgroups of patients show that individualized treatment options, rather than general approach, will result in better outcome.

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