Akut derin ven trombozu tanısının desteklenmesinde trombosit/lenfosit oranının kullanışlılığı

Amaç: Bu çalışmada, ortalama trombosit hacmi, kırmızı hücre dağılım genişliği, beyaz kan hücresi ve trombosit sayısı gibi rutin hemogram parametreleri ve trombosit/lenfosit oranı ve nötrofil/lenfosit oranı gibi yeni enflamatuvar biyobelirteçlerin akut derin ven trombozunun öngördücüleri olup olmadığı araştırıldı. Çalışma planı: Bu retrospektif çalışmaya Mart 2016 ve Ağustos 2018 tarihleri arasında akut alt ekstremite derin ven trombozu olan toplam 68 hasta (29 erkek, 39 kadın; ort. yaş 55.2±1.6 yıl; dağılım, 22-80 yıl) ve akut alt ekstremite derin ven trombozu olmayan 34 sağlıklı kontrol (15 erkek, 19 kadın; ort. yaş 52.8±2.5 yıl; dağılım 21-77 yıl) dahil edildi. Katılımcıların demografik ve klinik özellikleri ve hemogram parametreleri dahil olmak üzere laboratuvar verileri kaydedildi. Derin ven trombozunun anlamlı öngördürücülerini belirlemek için tek değişkenli ve çok değişkenli analizler yapıldı. Bulgular: Demografik ve klinik özellikler gruplar arasında benzerdi. Tek değişkenli analizde, trombosit sayısı ve kırmızı hücre dağılım genişliği, kontrol grubuna kıyasla, hasta grubunda anlamlı düzeyde yüksek bulundu. Ancak, kırmızı hücre dağılım genişliği, akut derin ven trombozunun anlamlı bir öngördürücüsü olarak belirlenmedi. Çok değişkenli lojistik regresyon analizine göre, trombosit/lenfosit oranı ve trombosit sayısı akut derin ven trombozunun anlamlı öngördürücüleri idi. Sonuç: Çalışma sonuçlarımız, trombosit/lenfosit oranının akut derin ven trombozu tanısını destekleyen yararlı bir biyobelirteç olabileceğini göstermektedir.

Utility of platelet-to-lymphocyte ratio to support the diagnosis of acute deep vein thrombosis

Background: The aim of this study was to investigate whetherroutine complete blood count parameters such as the meanplatelet volume, red cell distribution width, white blood celland platelet counts, and novel inflammatory biomarkers such asplatelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratiocould be used as the predictors of acute deep vein thrombosis.Methods: This retrospective study included a total of68 patients (29 males, 39 females; mean age 55.2±1.6 years;range, 22 to 80 years) with acute lower extremity deep veinthrombosis and 34 healthy controls (15 males, 19 females; meanage 52.8±2.5 years; range, 21 to 77 years) without acute lowerextremity deep vein thrombosis between March 2016 and August2018. Demographic and clinical characteristics of the participantand laboratory data including complete blood count parameterswere recorded. Univariate and multivariate analyses were used toidentify significant predictors of deep vein thrombosis.Results: Demographic and clinical characteristics were similarbetween the groups. According to the univariate analysis,platelet count and red cell distribution width were found tobe significantly higher in the patient group compared to thecontrol group. However, the red cell distribution width was notconsidered a significant predictor of acute deep vein thrombosis.According to the multivariate logistic regression analysis, theplatelet-to-lymphocyte ratio and platelet count were significantpredictors of acute deep vein thrombosis.Conclusion: Our study results show that the platelet-tolymphocyteratio may be a useful biomarker to support thediagnosis of acute deep vein thrombosis.

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