AIM: Although the most advance ultrasonography, by directly four dimensions looking the face, theabnormalities are hard to confirm. So, the first to be noticeable is suspicious and taken measurement forthe remarkable evidence is or not. In this Chapter, the evaluation of odd-looking infant is discussed.Grounding Aspects: The PossumCore and “Genetik Hastalıklarda Klinik Özellikler, GenetikDanışmanlık/Clinic specifications at the genetic diseases, EsOGÜ Pediatric Genetics DepartmentGuideline, January 2014” is the main source of the information.Introduction: The structure, the constitution of a baby; from genetically parents, thus, several influences areaffected the growth and development. Some factors as odd-looing is hard to identified and determined, likepolydactyly. The facial evaluation is discussed at this Unit.General Considerations; The perspective of the face is concern as; significantly abnormal, small, wide,premature looking, course, elfin, expressionless/hypotonic/myopathic. abnormal facial skin folds andcreases noticed one.Proceeding: As the general standardization of facial measurement, and the differentiation of the abnormality ispresented.Notions: In order to be evaluate, the general face structure have been indicated as; interpupillary distance,outer eyeball length, inner eyeball length, nose broad, palpebral fold length, and the ear structure, length, etc.Conclusion: The facial abnormalities as notices odd-looking is stated at this Chapter.