Zeynep TOPU, İsmail SAVAŞ

Meningeal karsinomatozisli bir küçük hücreli akciğer kanseri olgusu

Akciğer kanseri sonucunda gelişen beyin metastazı hastalığın kötü prognozuna işaret eder. Beyin, sık olarak gözlenen metastatik bir organ olup; metastazların %80'ini sıklık sırasına göre akciğer, meme, deri, böbrek, gastrointestinal sistem oluşturur. Akciğer kanselerinden özellikle küçük hücreli akciğer kanseri (KHAK)'nin santral sinir sistemi metastaz oranı yüksek olup, mortalitesi oldukça fazladır. Beyinde değişik yerleşimli metastazlar olmakla birlikte, leptomeningeal tutulum ilginç ve az görülen bir tutulum şeklidir. Bu makalede KHAK'ın leptomeningeal tutulumu nedeniyle tanıdan yedi ay sonra kaybedilen bir olgu sunulacaktır.

A patient with meningeal carcinomatosis and small cell lung cancer

Cranial methastase because of lung cancer shows the poor prognose. Cranial methastase is common: In order lung, breast, skin, kidney, gastrointestinal system cancer is the 80% of the cause of methastase. Cranial methastases are common in lung cancer especially in small cell lung cancer. Cranial methastase can be seen in different location but leptomeningeal infiltration is rare and interesting. Because of this we will describe a case which has been death seven months after diagnose because leptomeningeal infiltration of small cell lung cancer.

PDF

___

1. Tel N. Solunum sistemi. In: Cotron RS, Kumar V, Robbins SL (eds). Robbins Pathologic Basis of Disease. 4th ed. Turkish: Gunes Bookshops, 1992: 385-487.
2. Myklebust AT, Godal A, Fodstad O. Targeted therapy with immunotoxins in a nude rat model for leptomeningeal growth of human small cell lung cancer. Cancer Res 1994; 54: 2146-50.
3. Alexopoulus CG, Vaslamatsiz M, Patilla E, Taranto L. Central nervous system involvement and the prophylactic cranial irradiation in small cell lung cancer. Oncologist 1997; 2: 153-9.
4. Thirkill CE. Lung cancer-induced blindness. Lung Cancer 1996; 14: 253-64.
5. Rojas MI, Rene R, Graus F. Paraneoplastic syndromes in otoneuroophtalmology. Rev Neurol 2000; 31: 1206-12.
6. Dalmau J, Porta EJ. Paraneoplastic cerebral syndromes with oto-neuro-ophthalomologic manifestations. Rev Neurol 2000; 31: 1213-9.
7. Rosen ST, Aisner J, Makuch RW, et al. Carcinomatous leptomeningitis in small cell lung cancer: A clinicopatologic review of the National Cancer Institute Experience. Medicine (Baltimore) 1982; 61: 45-53.
8. Pedersan AG, Becker KL, Bach F, et al. Cerebrospinal fluid bombesin and calcitonin in patients with central nervous system metastases from small cell lung cancer. J Clin Oncol 1986; 4: 1620-7.
9. Fujimoto N, Hiraki A, Ueoka H, et al. Intramedullary spinal cord recurrence after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation for limited-disease small cell lung cancer. Lung Cancer 2000; 30: 145-8.
10. Onnoshi T, Ueoka H, Kiura K, et al. Meningeal carcinamatosis in patients with small cell lung cancer. Nihon Kyobu Shikkan Gakkai Zasshi 1993; 31: 324-9.
11. Ito K, Sudo A, Imail Y, et al. Intramedullary metastasis of small cell lung cancer. Nihon Kokyuki Gakkai Zasshi 1999; 37: 485-8.
12. Boogerd W, Vroom TM, van Heerde P, et al. CSF cytology versus immunocytochemistry in meningeal carcinomatosis. J Neurol Neurosurg Psychiatry 1988; 51: 142-5.