Metabolik sendrom

Metabolik Sendrom (MS), ortak etyopatogenezi paylaştıkları düşünülen risk faktörlerinin bir arada bulunmasıdır. Bu risk faktörleri, aterosklerotik hastalıklar, tip 2 diyabet ve kanserlerin ortaya çıkmasında çeşitli düzeylerde rol oynamaktadır. MS’un tanı kriterlerinde tam bir uzlaşma sağlanamamakla birlikte abdominal obezite, dislipidemi (hipertrigliseridemi, hiperkolesterolemi ve yüksek dansiteli lipoprotein düşüklüğü), hipertansiyon ve yüksek açlık kan şekerinin herhangi üçünün varlığında tanı konmaktadır. Metabolik Sendrom Araştırması’nın (METSAR) sonuçlarına göre Türkiye’de metabolik sendrom prevalansı %34; kadınlarda %40; erkeklerde %28’dir. Batı tipi beslenme ve obezitenin giderek yaygınlaşması sonucu, gerek dünyada gerekse Türkiye’de çocuk ve ergenlerde de metabolik sendrom görülmeye başlamıştır. Kronik hastalıkların ortaya çıkmasını kolaylaştıran bu sendromun, sağlıklı yaşam biçimi davranışları ile önlenebileceği düşünülmektedir.

Metabolic syndrome

Metabolic Syndrome is a combination of risk factors including common etiopathogenesis. These risk factors play different roles in occurence of atherosclerotic diseases, type 2 diabetes, and cancers. Although a compromise can not be achieved on differential diagnosis for MS, the existence of any three criterias enable to diagnose MS. These are abdominal obesity, dislipidemia (hypertrigliceridemia, hypercholesterolemia, and reduced high density lipoprotein) hypertension, and elevated fasting blood glucose. According to the results of Metabolic Syndrome Research (METSAR), the overall prevalence of MS in Turkey is 34%; in females 40%, and in males it is 28%. As a result of “Western” diet, and increased frequency of obesity, MS is observed in children and in adolescents both in the world and in Turkey. Resulting in chronic diseases, it is thought that the syndrome can be prevented by healthy lifestyle behaviours.

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1. Martinez MA, Puig JG, Mora M. et al. Metabolic syndrome: prevalence, associated factors, and C-reactive protein. Met Clin Experiment. 2008; 57: 1232-1240.
2. Baker R, Goodloe RJ, Larkin EK et al. Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study. BMC Proc 2009; 3(Suppl 7): S42.
3. Misra A, Khurana L. The Metabolic Syndrome in South Asians: Epidemiology, Determinants, and Prevention. Meta Syndr Relat Disord. 2009; 7(6): 497-514.
4. Tükiye’de Diyabet Profili. Diyabet Bakım, İzlem ve Tedavisinde Mevcut Durum Değerlendirmesi. Diyabetin Önlenmesi ve Korunma. 1. Çalışma Grubu Raporu. s. 17-47.
5. Hydrie MZI, Phil M, Shera AS et al. Prevalence of Metabolic Syndrome in Urban Pakistan (Karachi): Comparison of Newly Proposed International Diabetes Federation and Modified Adult Treatment Panel III Criteria. Meta Syndr Relat Disord. 2009; 7: 119-124.
6. Grundy SM, Cleeman JI, Daniels SR et al. Diagnosis and Management of the Metabolic Syndrome. An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 18: 2735-2752.
7. Bener A, Zirie M, Musallam M et al. Prevalence of Metabolic Syndrome According to Adult Treatment Panel III and International Diabetes Federation Criteria: A Population-Based Study. Meta Syndr Relat Disord. 2009; 7: 221-229.
8. Ekelund U, Anderssen S, Andersen LB et al. Prevalence and correlates of the metabolic syndrome in a population-based sample of European youth. Am J Clin Nutr. 2009; 89: 90-6.
9. Bokor S, Frelut ML, Vania A et al. Prevalence of metabolic syndrome in European obese children. Int J Ped Obes 2008; 3 (Suppl 2): 3-8.
10. Çizmecioğlu FM, Hatun Ş, Kalaça S. Metabolic syndrome in obese Turkish children and adolescents: comparison of two diagnostic models. Tur J Ped. 2008; 50: 359-365.
11. Kozan O, Oguz A, Abaci A, et al. Prevalence of the metabolic syndrome among Turkish adults. Eur J Clin Nutr. 2007; 61: 548-553 (METSAR).
12. Satman I, Yilmaz T, Sengul A, et al. Population-based study of diabetes and risk characteristics in Turkey: Results of the Turkish diabetes epidemiology study (TURDEP). Diab Care. 2002; 25: 1551-1556.
13. Onat A, Türkmen S, Karabulut A ve ark. Türk yetişkinlerinde hiperkolesterolemi ve hipertansiyon birlikteliği: sıklığına ve kardiyovasküler riski öngördürmesine ilişkin TEKFARF çalışması verileri. Türk Kardiyol Dern. 2004; 32: 397-405.
14. Onat A, Ceyhan K, Basar O, et al. Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels-a prospective and cross-sectional evaluation. Atherosclerosis. 2002; 165: 285-292.
15. Mahley RW, Palaoğlu E, Atak Z, et al. Turkish Heart Study: Lipids, lipoproteins, and apolipoproteins. J Lipid Res. 1995; 36: 839-859.
16. Goodman E, Daniels SR, Morrison JA et al. Contrasting prevalence of and demographic disparities in the World Health Organization and National Cholesterol Education Program Adult Treatment Panel III definitions of metabolic syndrome among adolescents. J Pediatr. 2004; 145: 445-451.
17. Cizmecioglu FM, Etiler N, Hamzaoglu O, Hatun S. Prevalence of Metabolic Syndrome in Schoolchildren and Adolescents in Turkey: a Population-based Study. J Ped Endoc Met. 2009; 8: 703-714.
18. Huang PL. A comprehensive definition for metabolic sydrome. Dis Model Mech. 2009; 2: 231-237.
19. Hadaegh F, Zabetian A, Tohidi M, et al. Prevalence of Metabolic Syndrome by the Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions and their Association with Coronary Heart Disease in an Elderly Iranian Population. Ann Acad Med Singapore. 2009; 38: 142-9.
20. Welin L, Adlerberth A, Caidahl K et al. Prevalence of cardiovascular risk factors and the metabolic syndrome in middle-aged men and women in Gothenburg, Sweden. BMC Public Hea. 2008; 403-411.
21. National Cholesterol Education Program Adult Treatment Panel III. Circulation. 2002; 106: 3143-3421.
22. Steyn NP, Mann J, Bennett PH et al. Diet, nutrition and the prevention of type 2 diabetes. Pub Health Nut. 2010; 7(IA): 147-165.
23. Can life style modifications using therapeutic lifestyle changes (TLC) reduce weight and the risk for chronic disease? National Center for Chronic Disease Prevention and Health Promotion Division of Nutrition, Physical Activity, and Obesity. www.cdc.gov Erişim: 29.01.2010.
24. T.C. Sağlık Bakanlığı, Temel Sağlık Hizmetleri Genel Müdürlüğü, Beslenme ve Fiziksel Aktiviteler_Daire_Başkanlığı_http://www.beslenme.saglik.gov.tr/index.php?pid=59&mNewsDetail=5 [Erişim Tarihi: 29.01.2010].