Mousumi KUNDU, Lalit Prashant MEENA, Kamlakar TRİPATHI, Richik TRIPATHI, Sarita PARIHAR, Amit Nandan DWIVEDI DHAR

Kronik periodontitli hastalarda kardiyovasküler riskin ciddiyetinin tahmini

AMAÇ: Kronik periodontal lezyon kardiyovasküler hastalıktan sorumlu olabilecek proinflamatuar sitokinleri açığa çıkarır. Bu çalışma kronik periodontitin oluşturduğ kardiyovasküler riski ortaya çıkarmak için yapılmıştır. YÖNTEM: Çalşma grubu kronik periodontitli 100 hasta ve kronik periodontiti olmayan 50 sağlıklı katılımcıdan oluşmaktadır. Her dişin periodontal indeksi Russel skoru kullanılarak hesaplanmıştır. Karotis intima-media kalınlığı 7,5 MHz lineer-array transdüseri ile, Ayak Bileği - Kol Basınç İndeksi sürekli dalgalı Dopler, ultrasonic jel ve tansiyon aleti ile ölçülmüştür. Hastalarda ve kontrollerde, tam kan sayımı ve serum lipid düzeyi otoanalizör ile, yüksek duyarlılıklı C-reaktif protein (hsCRP) ise ELISA yöntemi ile ölçüldü. RESULTS: Ortalama sağ ve sol karotis intima-media kalınlığı periodontitli hastalarda kontrollere gore anlamalı düzeyde daha yüksekti (p

[Estimation of cardiovascular risk severity in chronic periodontitis patients]

AIM: Chronic periodontal lesion releases pro-inflammatory cytokines which might be accountable for cardiovascular disease. This study was undertaken to access cardiovascular risk by chronic periodontitis. METHOD: The study group comprised of 100 patients with chronic periodontitis (CPD) and 50 healthy control without chronic periodontitis. Periodontal index of each tooth was calculated using Russel's score. Carotid Intima Media thickness (CIMT) was assessed with a 7.5-MHz linear-array transducer and Ankle-Brachial Pressure Indices (ABPI) were measured with a continuous-wave Doppler machine, ultrasonic gel, and a sphygmomanometer. Full blood counts were performed and levels of serum lipid were determined by autoanalyzer whereas high sensitive C-reactive protein (hsCRP) were measured by ELISA in patients and control. RESULTS: Mean left Carotid Intima Media thickness (CIMT) and mean right CIMT was significantly higher in patients as compared to control (p<0.001). Ankle brachial pressure index (ABPI) was not statistically significant between the two groups. Blood lipid profile was augmented in patient group as compare to control and hsCRP is also following the same pattern. CONCLUSION: Chronic periodontitis (CPD) is associated with increased risk of cardiovascular disease as evidenced by increased hsCRP and radiological parameters. Successful periodontal therapy could decrease serum inflammatory parameters.

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